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A Cystine-Rich Whey Supplement (Immunocal®) Provides Neuroprotection from Diverse Oxidative Stress-Inducing Agents In Vitro by Preserving Cellular Glutathione
Joint Authors
Winter, Aimee N.
Ross, Erika K.
Daliparthi, Vamsi
Sumner, Whitney A.
Kirchhof, Danielle M.
Manning, Evan
Wilkins, Heather M.
Linseman, Daniel A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-15
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Oxidative stress is a principal mechanism underlying the pathophysiology of neurodegeneration.
Therefore, nutritional enhancement of endogenous antioxidant defenses may represent a viable treatment option.
We investigated the neuroprotective properties of a unique whey protein supplement (Immunocal®) that provides an essential precursor (cystine) for synthesis of the endogenous antioxidant, glutathione (GSH).
Primary cultures of rat cerebellar granule neurons (CGNs), NSC34 motor neuronal cells, or HT22 hippocampal cells were preincubated in medium containing Immunocal and then subsequently treated with agents known to induce oxidative stress.
Immunocal protected CGNs against neurotoxicity induced by the Bcl-2 inhibitor, HA14-1, the nitric oxide donor, sodium nitroprusside, CuCl2, and AlCl3.
Immunocal also significantly reduced NSC34 cell death due to either H2O2 or glutamate and mitigated toxicity in HT22 cells overexpressing β-amyloid1-42.
The neuroprotective effects of Immunocal were blocked by inhibition of γ-glutamyl-cysteine ligase, demonstrating dependence on de novo GSH synthesis.
These findings indicate that sustaining GSH with Immunocal significantly protects neurons against diverse inducers of oxidative stress.
Thus, Immunocal is a nutritional supplement worthy of testing in preclinical animal models of neurodegeneration and in future clinical trials of patients afflicted by these diseases.
American Psychological Association (APA)
Winter, Aimee N.& Ross, Erika K.& Daliparthi, Vamsi& Sumner, Whitney A.& Kirchhof, Danielle M.& Manning, Evan…[et al.]. 2017. A Cystine-Rich Whey Supplement (Immunocal®) Provides Neuroprotection from Diverse Oxidative Stress-Inducing Agents In Vitro by Preserving Cellular Glutathione. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1194240
Modern Language Association (MLA)
Winter, Aimee N.…[et al.]. A Cystine-Rich Whey Supplement (Immunocal®) Provides Neuroprotection from Diverse Oxidative Stress-Inducing Agents In Vitro by Preserving Cellular Glutathione. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1194240
American Medical Association (AMA)
Winter, Aimee N.& Ross, Erika K.& Daliparthi, Vamsi& Sumner, Whitney A.& Kirchhof, Danielle M.& Manning, Evan…[et al.]. A Cystine-Rich Whey Supplement (Immunocal®) Provides Neuroprotection from Diverse Oxidative Stress-Inducing Agents In Vitro by Preserving Cellular Glutathione. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1194240
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194240