Synthesis, Characterization of Nano-β-Tricalcium Phosphate and the Inhibition on Hepatocellular Carcinoma Cells
Joint Authors
Dai, Honglian
Liu, Langlang
Wu, Yanzeng
Xu, Chao
Yu, Suchun
Wu, Xiaopei
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
It is difficult to synthesize nano-β-tricalcium phosphate (nano-β-TCP) owing to special crystal habit.
The aim of this work was to synthesize nano-β-TCP using ethanol-water system and characterize it by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Malvern laser particle size analyzer, and transmission electron microscope (TEM).
In addition, the inhibitory effect of nano-β-TCP on human hepatocellular carcinoma (HepG2) cells was also investigated using MTT assay, lactate dehydrogenase (LDH) leakage test, and 4′-6-diamidino-2-phenylindole (DAPI) staining.
The results showed that negatively charged rod-like nano-β-TCP with about 55 nm in diameter and 120 nm in length was synthesized, and the average particle size of nano-β-TCP was 72.7 nm.
The cell viability revealed that nano-β-TCP caused reduced cell viability of HepG2 cells in a time- and dose-dependent manner.
These findings presented here may provide valuable reference data to guide the design of nano-β-TCP-based anticancer drug carrier and therapeutic systems in the future.
American Psychological Association (APA)
Liu, Langlang& Wu, Yanzeng& Xu, Chao& Yu, Suchun& Wu, Xiaopei& Dai, Honglian. 2018. Synthesis, Characterization of Nano-β-Tricalcium Phosphate and the Inhibition on Hepatocellular Carcinoma Cells. Journal of Nanomaterials،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1194709
Modern Language Association (MLA)
Liu, Langlang…[et al.]. Synthesis, Characterization of Nano-β-Tricalcium Phosphate and the Inhibition on Hepatocellular Carcinoma Cells. Journal of Nanomaterials No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1194709
American Medical Association (AMA)
Liu, Langlang& Wu, Yanzeng& Xu, Chao& Yu, Suchun& Wu, Xiaopei& Dai, Honglian. Synthesis, Characterization of Nano-β-Tricalcium Phosphate and the Inhibition on Hepatocellular Carcinoma Cells. Journal of Nanomaterials. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1194709
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194709