Effect of Weight Loss, Exercise, or Both on Undercarboxylated Osteocalcin and Insulin Secretion in Frail, Obese Older Adults
Joint Authors
Napoli, Nicola
Villareal, Dennis T.
Armamento-Villareal, Reina
Colleluori, Georgia
Phadnis, Uma
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Obesity exacerbates age-related decline in glucometabolic control.
Undercarboxylated osteocalcin (UcOC) regulates pancreatic insulin secretion.
The long-term effect of lifestyle interventions on UcOC and insulin secretion has not been investigated.
Methods.
One hundred seven frail, obese older adults were randomized into the control (N=27), diet (N=26), exercise (N=26), and diet-exercise (N=28) groups for 1 year.
Main outcomes included changes in UcOC and disposition index (DI).
Results.
UcOC increased in the diet group (36 ± 11.6%) but not in the other groups (P<0.05 between groups).
Although similar increases in DI occurred in the diet-exercise and diet groups at 6 months, DI increased more in the diet-exercise group (92.4 ± 11.4%) than in the diet group (61.9 ± 15.3%) at 12 months (P<0.05).
UcOC and body composition changes predicted DI variation in the diet group only (R2=0.712), while adipocytokines and physical function changes contributed to DI variation in both the diet (∆R2=0.140 and 0.107) and diet-exercise (∆R2=0.427 and 0.243) groups (P<0.05 for all).
Conclusions.
Diet, but not exercise or both, increases UcOC, whereas both diet and diet-exercise increase DI.
UcOC accounts for DI variation only during active weight loss, while adipocytokines and physical function contribute to diet-exercise-induced DI variation, highlighting different mechanisms for lifestyle-induced improvements in insulin secretion.
This trial was registered with ClinicalTrials.gov number NCT00146107.
American Psychological Association (APA)
Colleluori, Georgia& Napoli, Nicola& Phadnis, Uma& Armamento-Villareal, Reina& Villareal, Dennis T.. 2017. Effect of Weight Loss, Exercise, or Both on Undercarboxylated Osteocalcin and Insulin Secretion in Frail, Obese Older Adults. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194808
Modern Language Association (MLA)
Colleluori, Georgia…[et al.]. Effect of Weight Loss, Exercise, or Both on Undercarboxylated Osteocalcin and Insulin Secretion in Frail, Obese Older Adults. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1194808
American Medical Association (AMA)
Colleluori, Georgia& Napoli, Nicola& Phadnis, Uma& Armamento-Villareal, Reina& Villareal, Dennis T.. Effect of Weight Loss, Exercise, or Both on Undercarboxylated Osteocalcin and Insulin Secretion in Frail, Obese Older Adults. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194808
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194808