PPAR-γ Activation Prevents Septic Cardiac Dysfunction via Inhibition of Apoptosis and Necroptosis
Joint Authors
Xu, Jun-mei
Li, Suobei
Ruan, Wei
Xiao, Feng
Peng, Shiyan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Sepsis-induced cardiac dysfunction remains one of the major causes of death in intensive care units.
Overwhelmed inflammatory response and unrestrained cell death play critical roles in sepsis-induced cardiac dysfunction.
Peroxisome proliferator-activated receptor- (PPAR-) γ has been proven to be cardioprotective in sepsis.
However, the mechanism of PPAR-γ-mediated cardioprotection and its relationship with inflammation and cell death are unclear.
We hypothesized that activation of PPAR-γ by reducing cardiac inflammation, myocardial apoptosis, and necroptosis may prevent myocardial dysfunction in sepsis.
Rats were subjected to cecal ligation and puncture (CLP) with or without PPAR-γ agonist (rosiglitazone) or antagonist T0070907 (T007).
After CLP, cardiac function was significantly depressed, which was associated with the destructed myocardium, upregulated proinflammatory cytokines, and increased apoptosis, necrosis, and necroptosis.
This process is corresponded with decreased inhibitor κB (IκBα) and increased NF-κB, receptor-interacting protein kinase-1 (RIP1), RIP3, and mixed lineage kinase-like (MLKL) protein.
Activation of PPAR-γ by rosiglitazone pretreatment enhanced PPAR-γ activity and prevented these changes, thereby improving the survival of septic rats.
In contrast, inhibition of PPAR-γ by T007 further exacerbated the condition, dropping the survival rate to nearly 0%.
In conclusion, PPAR-γ activation by reducing proinflammatory cytokines, apoptosis, and necroptosis in the myocardium prevents septic myocardial dysfunction.
American Psychological Association (APA)
Peng, Shiyan& Xu, Jun-mei& Ruan, Wei& Li, Suobei& Xiao, Feng. 2017. PPAR-γ Activation Prevents Septic Cardiac Dysfunction via Inhibition of Apoptosis and Necroptosis. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1196000
Modern Language Association (MLA)
Peng, Shiyan…[et al.]. PPAR-γ Activation Prevents Septic Cardiac Dysfunction via Inhibition of Apoptosis and Necroptosis. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1196000
American Medical Association (AMA)
Peng, Shiyan& Xu, Jun-mei& Ruan, Wei& Li, Suobei& Xiao, Feng. PPAR-γ Activation Prevents Septic Cardiac Dysfunction via Inhibition of Apoptosis and Necroptosis. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1196000
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196000