A Single Zidovudine (AZT) Administration Delays Hepatic Cell Proliferation by Altering Oxidative State in the Regenerating Rat Liver
Joint Authors
Sánchez-Sevilla, Lourdes
Hernández-Muñoz, Rolando
Butanda-Ochoa, Armando
Hernández-Espinosa, Diego Rolando
Rodríguez, Mario R.
Chávez-Rentería, Benito
Aranda-Fraustro, Alberto
Olguín-Martínez, Marisela
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-05
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The 3′-azido-3′-deoxythymidine or Zidovudine (AZT) was the first antiretroviral drug used in the treatment of HIV patients, which has good effectiveness but also hepatotoxic side effects that include cell cycle arrest and oxidative/nitrative mitochondrial damage.
Whether such an oxidative damage may affect the proliferative-regenerative capacity of liver remains to be clearly specified at doses commonly used in the clinical practice.
In this study, we described the oxidative-proliferative effect of AZT administered at a common clinical dose in rat liver submitted to 70% partial hepatectomy (PH).
The results indicate that AZT significantly decreased DNA synthesis and the number of mitosis in liver subjected to PH in a synchronized way with the promotion of organelle-selective lipid peroxidation events (especially those observed in plasma membrane and cytosolic fractions) and with liver enzyme release to the bloodstream.
Then at the dose used in clinical practice AZT decreased liver regeneration but stimulates oxidative events involved during the proliferation process in a way that each membrane system inside the cell preserves its integrity in order to maintain the cell proliferative process.
Here, the induction of large amounts of free ammonia in the systemic circulation could become a factor capable of mediating the deleterious effects of AZT on PH-induced rat liver regeneration.
American Psychological Association (APA)
Butanda-Ochoa, Armando& Hernández-Espinosa, Diego Rolando& Olguín-Martínez, Marisela& Sánchez-Sevilla, Lourdes& Rodríguez, Mario R.& Chávez-Rentería, Benito…[et al.]. 2017. A Single Zidovudine (AZT) Administration Delays Hepatic Cell Proliferation by Altering Oxidative State in the Regenerating Rat Liver. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1196006
Modern Language Association (MLA)
Butanda-Ochoa, Armando…[et al.]. A Single Zidovudine (AZT) Administration Delays Hepatic Cell Proliferation by Altering Oxidative State in the Regenerating Rat Liver. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1196006
American Medical Association (AMA)
Butanda-Ochoa, Armando& Hernández-Espinosa, Diego Rolando& Olguín-Martínez, Marisela& Sánchez-Sevilla, Lourdes& Rodríguez, Mario R.& Chávez-Rentería, Benito…[et al.]. A Single Zidovudine (AZT) Administration Delays Hepatic Cell Proliferation by Altering Oxidative State in the Regenerating Rat Liver. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1196006
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196006