Melatonin Supplementation Lowers Oxidative Stress and Regulates Adipokines in Obese Patients on a Calorie-Restricted Diet
Joint Authors
Rajewski, Paweł
Woźniak, Alina
Sutkowy, Paweł
Wesołowski, Roland
Szewczyk-Golec, Karolina
Pawłowska, M.
Gackowski, Marcin
Mila-Kierzenkowska, Celestyna
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Obesity is one of the major global health problems.
Melatonin deficiency has been demonstrated to correlate with obesity.
The aim of the study was to estimate the effect of melatonin on oxidative stress and adipokine levels in obese patients on a calorie-restricted diet.
Thirty obese patients were supplemented with a daily dose of 10 mg of melatonin (n=15) or placebo (n=15) for 30 days with a calorie-restricted diet.
Serum levels of melatonin, 4-hydroxynonenal (HNE), adiponectin, omentin-1, leptin, and resistin, as well as erythrocytic malondialdehyde (MDA) concentration and Zn/Cu-superoxide dismutase, catalase, and glutathione peroxidase (GPx) activities, were measured at baseline and after supplementation.
Significant body weight reduction was observed only in the melatonin group.
After melatonin supplementation, the adiponectin and omentin-1 levels and GPx activities statistically increased, whereas the MDA concentrations were reduced.
In the placebo group, a significant rise in the HNE and a drop in the melatonin concentrations were found.
The results show evidence of increased oxidative stress accompanying calorie restriction.
Melatonin supplementation facilitated body weight reduction, improved the antioxidant defense, and regulated adipokine secretion.
The findings strongly suggest that melatonin should be considered in obesity management.
This trial is registered with CTRI/2017/07/009093.
American Psychological Association (APA)
Szewczyk-Golec, Karolina& Rajewski, Paweł& Gackowski, Marcin& Mila-Kierzenkowska, Celestyna& Wesołowski, Roland& Sutkowy, Paweł…[et al.]. 2017. Melatonin Supplementation Lowers Oxidative Stress and Regulates Adipokines in Obese Patients on a Calorie-Restricted Diet. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1196115
Modern Language Association (MLA)
Szewczyk-Golec, Karolina…[et al.]. Melatonin Supplementation Lowers Oxidative Stress and Regulates Adipokines in Obese Patients on a Calorie-Restricted Diet. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1196115
American Medical Association (AMA)
Szewczyk-Golec, Karolina& Rajewski, Paweł& Gackowski, Marcin& Mila-Kierzenkowska, Celestyna& Wesołowski, Roland& Sutkowy, Paweł…[et al.]. Melatonin Supplementation Lowers Oxidative Stress and Regulates Adipokines in Obese Patients on a Calorie-Restricted Diet. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1196115
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196115