Dual-Task Performance in GBA Parkinson’s Disease
Joint Authors
Maetzler, Walter
Srulijes, Karin
Brockmann, Kathrin
Ogbamicael, Senait
Hobert, Markus A.
Hauser, Ann-Kathrin
Schulte, Claudia
Fritzen, Jasmin
Schwenk, Michael
Gasser, Thomas
Berg, Daniela
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Parkinson’s disease patients carrying a heterozygous mutation in the gene glucocerebrosidase (GBA-PD) show faster motor and cognitive decline than idiopathic Parkinson’s disease (iPD) patients, but the mechanisms behind this observation are not well understood.
Successful dual tasking (DT) requires a smooth integration of motor and nonmotor operations.
This study compared the DT performances between GBA-PD and iPD patients.
Methods.
Eleven GBA-PD patients (p.N370S, p.L444P) and eleven matched iPD patients were included.
Clinical characterization included a motor score (Unified PD Rating Scale-III, UPDRS-III) and nonmotor scores (Montreal Cognitive Assessment, MoCA, and Beck’s Depression Inventory).
Quantitative gait analysis during the single-task (ST) and DT assessments was performed using a wearable sensor unit.
These parameters corrected for UPDRS and MoCA were then compared between the groups.
Results.
Under the DT condition “walking while checking boxes,” GBA-PD patients showed slower gait and box-checking speeds than iPD patients.
GBA-PD and iPD patients did not show significant differences regarding dual-task costs.
Conclusion.
This pilot study suggests that DT performance with a secondary motor task is worse in GBA-PD than in iPD patients.
This finding may be associated with the known enhanced motor and cognitive deficits in GBA-PD compared to iPD and should motivate further studies.
American Psychological Association (APA)
Srulijes, Karin& Brockmann, Kathrin& Ogbamicael, Senait& Hobert, Markus A.& Hauser, Ann-Kathrin& Schulte, Claudia…[et al.]. 2017. Dual-Task Performance in GBA Parkinson’s Disease. Parkinson’s Disease،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1197146
Modern Language Association (MLA)
Srulijes, Karin…[et al.]. Dual-Task Performance in GBA Parkinson’s Disease. Parkinson’s Disease No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1197146
American Medical Association (AMA)
Srulijes, Karin& Brockmann, Kathrin& Ogbamicael, Senait& Hobert, Markus A.& Hauser, Ann-Kathrin& Schulte, Claudia…[et al.]. Dual-Task Performance in GBA Parkinson’s Disease. Parkinson’s Disease. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1197146
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197146