Depression in Parkinson’s Disease: The Contribution from Animal Studies
Joint Authors
Ferro, Marcelo Machado
Fontoura, Jéssica Lopes
Baptista, Camila
Pedroso, Flávia de Brito
Pochapski, José Augusto
Miyoshi, Edmar
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Besides being better known for causing motor impairments, Parkinson’s disease (PD) can also cause many nonmotor symptoms, like depression and anxiety, which can cause significant loss of life quality and may not respond to regular drugs treatment.
In this review, we discuss the depression in PD, based on data from studies in humans and rodents.
Depression frequency seems higher in PD patients than in general population, despite high variation in data due to diagnosis disparities.
Development of depression in PD seems more likely to be caused by the nigrostriatal pathway degeneration than as a consequence of the awareness of disease prognostic, and it seems to be related to dopaminergic, noradrenergic, and serotoninergic synapses deficits.
The dopaminergic role could be more significant, since it can modulate the release of the others, and its depletion is progressive, due to the degenerative feature of PD.
Highly regarded in major depression, serotonin can be depleted in rats after nigrostriatal damage, but data from human patients are more conflicting.
Animal studies can help in understanding the neurobiological mechanisms of depression in PD and the pursuit for more effective drugs for its treatment, but they lack the complexity of the disease progression, especially the nondopaminergic degeneration.
American Psychological Association (APA)
Fontoura, Jéssica Lopes& Baptista, Camila& Pedroso, Flávia de Brito& Pochapski, José Augusto& Miyoshi, Edmar& Ferro, Marcelo Machado. 2017. Depression in Parkinson’s Disease: The Contribution from Animal Studies. Parkinson’s Disease،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1197153
Modern Language Association (MLA)
Fontoura, Jéssica Lopes…[et al.]. Depression in Parkinson’s Disease: The Contribution from Animal Studies. Parkinson’s Disease No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1197153
American Medical Association (AMA)
Fontoura, Jéssica Lopes& Baptista, Camila& Pedroso, Flávia de Brito& Pochapski, José Augusto& Miyoshi, Edmar& Ferro, Marcelo Machado. Depression in Parkinson’s Disease: The Contribution from Animal Studies. Parkinson’s Disease. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1197153
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197153