Phosphorylated α-Synuclein-Copper Complex Formation in the Pathogenesis of Parkinson’s Disease
Joint Authors
Montes-de-Oca-Luna, Roberto
Castillo-Gonzalez, Juan Antonio
Loera-Arias, Maria De Jesus
Saucedo-Cardenas, Odila
Garcia-Garcia, Aracely
Rodriguez-Rocha, Humberto
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Parkinson’s disease is the second most important neurodegenerative disorder worldwide.
It is characterized by the presence of Lewy bodies, which are mainly composed of α-synuclein and ubiquitin-bound proteins.
Both the ubiquitin proteasome system (UPS) and autophagy-lysosomal pathway (ALS) are altered in Parkinson’s disease, leading to aggregation of proteins, particularly α-synuclein.
Interestingly, it has been observed that copper promotes the protein aggregation process.
Additionally, phosphorylation of α-synuclein along with copper also affects the protein aggregation process.
The interrelation among α-synuclein phosphorylation and its capability to interact with copper, with the subsequent disruption of the protein degradation systems in the neurodegenerative process of Parkinson’s disease, will be analyzed in detail in this review.
American Psychological Association (APA)
Castillo-Gonzalez, Juan Antonio& Loera-Arias, Maria De Jesus& Saucedo-Cardenas, Odila& Montes-de-Oca-Luna, Roberto& Garcia-Garcia, Aracely& Rodriguez-Rocha, Humberto. 2017. Phosphorylated α-Synuclein-Copper Complex Formation in the Pathogenesis of Parkinson’s Disease. Parkinson’s Disease،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1197155
Modern Language Association (MLA)
Castillo-Gonzalez, Juan Antonio…[et al.]. Phosphorylated α-Synuclein-Copper Complex Formation in the Pathogenesis of Parkinson’s Disease. Parkinson’s Disease No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1197155
American Medical Association (AMA)
Castillo-Gonzalez, Juan Antonio& Loera-Arias, Maria De Jesus& Saucedo-Cardenas, Odila& Montes-de-Oca-Luna, Roberto& Garcia-Garcia, Aracely& Rodriguez-Rocha, Humberto. Phosphorylated α-Synuclein-Copper Complex Formation in the Pathogenesis of Parkinson’s Disease. Parkinson’s Disease. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1197155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197155