Myocardial Expression of PPARγ and Exercise Capacity in Patients after Coronary Artery Bypass Surgery
Joint Authors
Piotrowicz, Ryszard
Wojtkowska, Izabela
Tysarowski, Andrzej
Seliga, Katarzyna
Stępińska, Janina
Bonda, Tomasz A.
Wolszakiewicz, Jadwiga
Osak, Jerzy
Winnicka, Maria M.
Siedlecki, Janusz A.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Activation of PPARs may be involved in the development of heart failure (HF).
We evaluated the relationship between expression of PPARγ in the myocardium during coronary artery bypass grafting (CABG) and exercise tolerance initially and during follow-up.
6-minute walking test was performed before CABG, after 1, 12, 24 months.
Patients were divided into two groups (HF and non-HF) based on left ventricular ejection fraction and plasma proBNP level.
After CABG, 67% of patients developed HF.
The mean distance 1 month after CABG in HF was 397±85 m versus 420±93 m in non-HF.
PPARγ mRNA expression was similar in both HF and non-HF groups.
6MWT distance 1 month after CABG was inversely correlated with PPARγ level only in HF group.
Higher PPARγ expression was related to smaller LVEF change between 1 month and 1 year (R=0.18, p<0.05), especially in patients with HF.
Higher initial levels of IL-6 in HF patients were correlated with longer distance in 6MWT one month after surgery and lower PPARγ expression.
PPARγ expression is not related to LVEF before CABG and higher PPARγ expression in the myocardium of patients who are developing HF following CABG may have some protecting effect.
American Psychological Association (APA)
Wojtkowska, Izabela& Bonda, Tomasz A.& Wolszakiewicz, Jadwiga& Osak, Jerzy& Tysarowski, Andrzej& Seliga, Katarzyna…[et al.]. 2017. Myocardial Expression of PPARγ and Exercise Capacity in Patients after Coronary Artery Bypass Surgery. PPAR Research،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1197194
Modern Language Association (MLA)
Wojtkowska, Izabela…[et al.]. Myocardial Expression of PPARγ and Exercise Capacity in Patients after Coronary Artery Bypass Surgery. PPAR Research No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1197194
American Medical Association (AMA)
Wojtkowska, Izabela& Bonda, Tomasz A.& Wolszakiewicz, Jadwiga& Osak, Jerzy& Tysarowski, Andrzej& Seliga, Katarzyna…[et al.]. Myocardial Expression of PPARγ and Exercise Capacity in Patients after Coronary Artery Bypass Surgery. PPAR Research. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1197194
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197194