PPARγ and Its Role in Cardiovascular Diseases
Joint Authors
Chandra, Mini
Miriyala, Sumitra
Panchatcharam, Manikandan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Peroxisome proliferator-activated receptor Gamma (PPARγ), a ligand-activated transcription factor, has a role in various cellular functions as well as glucose homeostasis, lipid metabolism, and prevention of oxidative stress.
The activators of PPARγ are already widely used in the treatment of diabetes mellitus.
The cardioprotective effect of PPARγ activation has been studied extensively over the years making them potential therapeutic targets in diseases associated with cardiovascular disorders.
However, they are also associated with adverse cardiovascular events such as congestive heart failure and myocardial infarction.
This review aims to discuss the role of PPARγ in the various cardiovascular diseases and summarize the current knowledge on PPARγ agonists from multiple clinical trials.
Finally, we also review the new PPARγ agonists under development as potential therapeutics with reduced or no adverse effects.
American Psychological Association (APA)
Chandra, Mini& Miriyala, Sumitra& Panchatcharam, Manikandan. 2017. PPARγ and Its Role in Cardiovascular Diseases. PPAR Research،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1197266
Modern Language Association (MLA)
Chandra, Mini…[et al.]. PPARγ and Its Role in Cardiovascular Diseases. PPAR Research No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1197266
American Medical Association (AMA)
Chandra, Mini& Miriyala, Sumitra& Panchatcharam, Manikandan. PPARγ and Its Role in Cardiovascular Diseases. PPAR Research. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1197266
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197266