Low IL-6, IL-10, and TNF-α and High IL-13 Cytokine Levels Are Associated with Severe Hepatic Fibrosis in Schistosoma mansoni Chronically Exposed Individuals
Joint Authors
Musonda, Patrick
Mduluza, Takafira
Mutengo, Mable M.
Kelly, Paul
Mwansa, James C. L.
Kwenda, Geoffrey
Chipeta, James
Source
Journal of Parasitology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Several studies have attributed the etiopathogenesis of chronic Schistosoma mansoni related hepatic fibrosis to unregulated immune responses against trapped parasite ova in the host.
However, there is limited data on immune profiles associated with varying degrees of the disease in a population under chronic exposure to the parasite.
We therefore investigated the role of selected T-helper (Th)1, Th2, and Th17 cytokines in relation to hepatic fibrosis severity among individuals resident in a hyper-Schistosoma mansoni endemic region of Western Zambia.
Two hundred and forty-four S.
mansoni infected individuals with and without fibrosis were analysed for cytokine profiles.
Based on hepatic fibrosis stage as determined by ultrasound, participants were categorized into Group 0, Group I, Group II, and Group III.
Cytokines were measured in S.
mansoni egg stimulated whole blood culture supernatants using the BD Cytometric Bead Array kits.
Compared to the nonfibrotic group, participants in the severe hepatic fibrotic group produced less interleukin- (IL-) 6, IL-10, and tumour necrosis factor-alpha (TNF-α).
On the other hand, IL-13 was significantly elevated in this group compared to the nonfibrotic group (p<0.001).
Our results suggest that low IL-6, IL-10, and TNF-α and high IL-13 levels may influence S.
mansoni disease progression.
American Psychological Association (APA)
Mutengo, Mable M.& Mduluza, Takafira& Kelly, Paul& Mwansa, James C. L.& Kwenda, Geoffrey& Musonda, Patrick…[et al.]. 2018. Low IL-6, IL-10, and TNF-α and High IL-13 Cytokine Levels Are Associated with Severe Hepatic Fibrosis in Schistosoma mansoni Chronically Exposed Individuals. Journal of Parasitology Research،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1197635
Modern Language Association (MLA)
Mutengo, Mable M.…[et al.]. Low IL-6, IL-10, and TNF-α and High IL-13 Cytokine Levels Are Associated with Severe Hepatic Fibrosis in Schistosoma mansoni Chronically Exposed Individuals. Journal of Parasitology Research No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1197635
American Medical Association (AMA)
Mutengo, Mable M.& Mduluza, Takafira& Kelly, Paul& Mwansa, James C. L.& Kwenda, Geoffrey& Musonda, Patrick…[et al.]. Low IL-6, IL-10, and TNF-α and High IL-13 Cytokine Levels Are Associated with Severe Hepatic Fibrosis in Schistosoma mansoni Chronically Exposed Individuals. Journal of Parasitology Research. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1197635
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197635