Protective effects of α-lipoic acid on hepatic and renal biomarkers and histological changes induced by α-cypermethrin in treated male rats
Other Title(s)
التأثيرات الوقائية لحمض ألفا ليبويك على المؤشرات الحيوية الكبدية و الكلوية و التغيرات الهستولوجية المستحثة بألفا سيبرمثرين في ذكور الجرذان المعالجة
Author
al-Umayr, Muhammad Bin Abd Allah
Source
Scientific Journal of King Faisal University : Basic and Applied Sciences
Issue
Vol. 20, Issue 2 (31 Dec. 2019), pp.23-33, 11 p.
Publisher
Publication Date
2019-12-31
Country of Publication
Saudi Arabia
No. of Pages
11
Main Subjects
Abstract EN
α-Cypermethrin is a synthetic type II pyrethroid insecticide.
Earlier works have revealed the argumentative influence of α-cypermethrin on liver and kidney.
This work aimed to estimate the potential character of α-lipoic acid in the induced toxicity of α-cypermethrin in the kidney and liver of male albino rats.
Examined rats were alienated into four groups as following; α-cypermethrin/α- lipoic acid, α-lipoic acid, α-cypermethin as well as control.
The results of this study showed that administration of α- cypermethrin caused a significant increase in the activity of ALT (Alanine Transaminase), AST (Aspartate Transaminase), ALP (Alkaline Phosphatase), the level of bilirubin, urea, uric acid, and creatinine, as well as decreased levels of total protein and albumin.
Moreover, the presence of α- lipoic acid alleviates the harmfulness of α-cypermethrin by moderately regularizing these biochemical factors.
The biochemical markers were maintained by the histological investigation.
Our outcomes proposed that α- lipoic acid might play a defensive role in the induced toxicity of α- cypermethrin in the kidney and liver of treated rats.
American Psychological Association (APA)
al-Umayr, Muhammad Bin Abd Allah. 2019. Protective effects of α-lipoic acid on hepatic and renal biomarkers and histological changes induced by α-cypermethrin in treated male rats. Scientific Journal of King Faisal University : Basic and Applied Sciences،Vol. 20, no. 2, pp.23-33.
https://search.emarefa.net/detail/BIM-1200312
Modern Language Association (MLA)
al-Umayr, Muhammad Bin Abd Allah. Protective effects of α-lipoic acid on hepatic and renal biomarkers and histological changes induced by α-cypermethrin in treated male rats. Scientific Journal of King Faisal University : Basic and Applied Sciences Vol. 20, no. 2 (Dec. 2019), pp.23-33.
https://search.emarefa.net/detail/BIM-1200312
American Medical Association (AMA)
al-Umayr, Muhammad Bin Abd Allah. Protective effects of α-lipoic acid on hepatic and renal biomarkers and histological changes induced by α-cypermethrin in treated male rats. Scientific Journal of King Faisal University : Basic and Applied Sciences. 2019. Vol. 20, no. 2, pp.23-33.
https://search.emarefa.net/detail/BIM-1200312
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-1200312