The Holy Grail of Orthopedic Surgery: Mesenchymal Stem Cells—Their Current Uses and Potential Applications
Joint Authors
Granados, Julio
Gómez-García, R.
Granados-Montiel, Julio
Berebichez-Fridman, Roberto
Berebichez-Fastlicht, Enrique
Olivos-Meza, Anell
Velasquillo, Cristina
Ibarra, Clemente
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-18
Country of Publication
Egypt
No. of Pages
14
Abstract EN
Only select tissues and organs are able to spontaneously regenerate after disease or trauma, and this regenerative capacity diminishes over time.
Human stem cell research explores therapeutic regenerative approaches to treat various conditions.
Mesenchymal stem cells (MSCs) are derived from adult stem cells; they are multipotent and exert anti-inflammatory and immunomodulatory effects.
They can differentiate into multiple cell types of the mesenchyme, for example, endothelial cells, osteoblasts, chondrocytes, fibroblasts, tenocytes, vascular smooth muscle cells, and sarcomere muscular cells.
MSCs are easily obtained and can be cultivated and expanded in vitro; thus, they represent a promising and encouraging treatment approach in orthopedic surgery.
Here, we review the application of MSCs to various orthopedic conditions, namely, orthopedic trauma; muscle injury; articular cartilage defects and osteoarthritis; meniscal injuries; bone disease; nerve, tendon, and ligament injuries; spinal cord injuries; intervertebral disc problems; pediatrics; and rotator cuff repair.
The use of MSCs in orthopedics may transition the practice in the field from predominately surgical replacement and reconstruction to bioregeneration and prevention.
However, additional research is necessary to explore the safety and effectiveness of MSC treatment in orthopedics, as well as applications in other medical specialties.
American Psychological Association (APA)
Berebichez-Fridman, Roberto& Gómez-García, R.& Granados-Montiel, Julio& Berebichez-Fastlicht, Enrique& Olivos-Meza, Anell& Granados, Julio…[et al.]. 2017. The Holy Grail of Orthopedic Surgery: Mesenchymal Stem Cells—Their Current Uses and Potential Applications. Stem Cells International،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1201022
Modern Language Association (MLA)
Berebichez-Fridman, Roberto…[et al.]. The Holy Grail of Orthopedic Surgery: Mesenchymal Stem Cells—Their Current Uses and Potential Applications. Stem Cells International No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1201022
American Medical Association (AMA)
Berebichez-Fridman, Roberto& Gómez-García, R.& Granados-Montiel, Julio& Berebichez-Fastlicht, Enrique& Olivos-Meza, Anell& Granados, Julio…[et al.]. The Holy Grail of Orthopedic Surgery: Mesenchymal Stem Cells—Their Current Uses and Potential Applications. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1201022
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201022