In Utero Stem Cell Transplantation: Potential Therapeutic Application for Muscle Diseases
Joint Authors
Asakura, Atsushi
Chowdhury, Neeladri
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-17
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Muscular dystrophies, myopathies, and traumatic muscle injury and loss encompass a large group of conditions that currently have no cure.
Myoblast transplantations have been investigated as potential cures for these conditions for decades.
However, current techniques lack the ability to generate cell numbers required to produce any therapeutic benefit.
In utero stem cell transplantation into embryos has been studied for many years mainly in the context of hematopoietic cells and has shown to have experimental advantages and therapeutic applications.
Moreover, patient-derived cells can be used for experimental transplantation into nonhuman animal embryos via in utero injection as the immune response is absent at such early stages of development.
We therefore propose in utero transplantation as a potential method to generate patient-derived humanized skeletal muscle as well as muscle stem cells in animals for therapeutic purposes as well as patient-specific drug screening.
American Psychological Association (APA)
Chowdhury, Neeladri& Asakura, Atsushi. 2017. In Utero Stem Cell Transplantation: Potential Therapeutic Application for Muscle Diseases. Stem Cells International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1201103
Modern Language Association (MLA)
Chowdhury, Neeladri& Asakura, Atsushi. In Utero Stem Cell Transplantation: Potential Therapeutic Application for Muscle Diseases. Stem Cells International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1201103
American Medical Association (AMA)
Chowdhury, Neeladri& Asakura, Atsushi. In Utero Stem Cell Transplantation: Potential Therapeutic Application for Muscle Diseases. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1201103
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201103