Human Chorionic Plate-Derived Mesenchymal Stem Cells Restore Hepatic Lipid Metabolism in a Rat Model of Bile Duct Ligation

Joint Authors

Yoon, Jung-Hwan
Choi, Jong Ho
Lee, Yun Bin
Kim, Gi Jin
Kim, Eun Nam
Seok, Jin
Lee, Hyun-Jung

Source

Stem Cells International

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-11-09

Country of Publication

Egypt

No. of Pages

9

Abstract EN

In cholestatic liver diseases, impaired bile excretion disrupts lipid homeostasis.

We investigated changes of lipid metabolism, including mitochondrial β-oxidation, in a rat model of bile duct ligation (BDL) in which chorionic plate-derived mesenchymal stem cells (CP-MSCs) were transplanted.

Serum cholesterol level, which was elevated after BDL, was significantly decreased following CP-MSC transplantation.

The expression levels of genes involved in intracellular lipid uptake, including long-chain fatty acyl-CoA synthetases and fatty acid transport proteins, were decreased in rats after BDL; however, they were not significantly changed by subsequent CP-MSC transplantation.

Carnitine palmitoyltransferase 1A (CPT1A), a rate-limiting enzyme in mitochondrial β-oxidation, was upregulated after BDL and then was downregulated after CP-MSC transplantation.

CPT1A expression was changed via microRNA-33—a posttranscriptional regulator of CPT1A—in a peroxisome proliferator-activated receptor α-independent manner.

Cellular adenosine triphosphate production—an indicator of mitochondrial function—was reduced after BDL and was restored by CP-MSC transplantation.

Expression levels of heme oxygenases also were significantly affected following BDL and CP-MSC transplantation.

Lipid metabolism is altered in response to chronic cholestatic liver injury and can be restored by CP-MSC transplantation.

Our study findings support the therapeutic potential of CP-MSCs in cholestatic liver diseases and help in understanding the fundamental mechanisms by which CP-MSCs affect energy metabolism.

American Psychological Association (APA)

Lee, Yun Bin& Choi, Jong Ho& Kim, Eun Nam& Seok, Jin& Lee, Hyun-Jung& Yoon, Jung-Hwan…[et al.]. 2017. Human Chorionic Plate-Derived Mesenchymal Stem Cells Restore Hepatic Lipid Metabolism in a Rat Model of Bile Duct Ligation. Stem Cells International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1201734

Modern Language Association (MLA)

Lee, Yun Bin…[et al.]. Human Chorionic Plate-Derived Mesenchymal Stem Cells Restore Hepatic Lipid Metabolism in a Rat Model of Bile Duct Ligation. Stem Cells International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1201734

American Medical Association (AMA)

Lee, Yun Bin& Choi, Jong Ho& Kim, Eun Nam& Seok, Jin& Lee, Hyun-Jung& Yoon, Jung-Hwan…[et al.]. Human Chorionic Plate-Derived Mesenchymal Stem Cells Restore Hepatic Lipid Metabolism in a Rat Model of Bile Duct Ligation. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1201734

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1201734