2-Allylphenol Reduces IL-1β and TNF-α, Promoting Antinociception through Adenosinergic, Anti-Inflammatory, and Antioxidant Mechanisms
Joint Authors
Barbosa Filho, José Maria
Cavalcante-Silva, Luiz Henrique Agra
Galvão, José Guilherme Marques
Scotti, Marcus Tullius
Rodrigues-Mascarenhas, Sandra
Aragão Neto, Humberto de Carvalho
da Fonsêca, Diogo Vilar
Braga, Renan Marinho
do Nascimento, Terezinha Weyne Araújo Borges
Assis, Davidson Barbosa
Vidal, Arthur Antunes Jacome
Rocha, Hugo Alexandre Oliveira
de Almeida, Reinaldo Nóbrega
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-31
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
2-Allylphenol (2-AP) is a synthetic phenylpropanoid, structurally related to cardanol, thymol, and ortho-eugenol.
Phenylpropanoids are described in the literature as being capable of promoting biological activity.
Due to the similarity between 2-AP and other bioactive phenylpropanoids, the present research aims at evaluating the antioxidant, antinociceptive, and anti-inflammatory potential of 2-AP in silico, in vitro, and in vivo.
At 30 min prior to the start of in vivo pharmacological testing, administration of 2-AP (25, 50, 75, and 100 mg/kg i.p.), morphine (6 mg/kg i.p.), dexamethasone (2 mg/kg s.c.), or vehicle alone was performed.
In the acetic acid-induced abdominal writhing tests, pretreatment with 2-AP significantly reduced the number of abdominal writhes, as well as decreased licking times in the glutamate and formalin tests.
Investigation of the mechanism of action using the formalin model led to the conclusion that the opioid system does not participate in its activity.
However, the adenosinergic system is involved.
In the peritonitis tests, 2-AP inhibited leukocyte migration and reduced releases of proinflammatory mediators TNF-α and IL-1β.
In vitro antioxidant assays demonstrated that 2-AP presents significant ability to sequester superoxide radicals.
In silico docking studies confirmed interaction between 2-AP and the adenosine A2a receptor through hydrogen bonds with the critical asparagine 253 residues present in the active site.
Investigation of 2-AP demonstrated its nociception inhibition and ability to reduce reactive oxygen species.
Its interaction with A2a receptors may well be related to proinflammatory cytokines TNF-α and IL-1β reduction activity, corroborating its antinociceptive effect.
American Psychological Association (APA)
Aragão Neto, Humberto de Carvalho& da Fonsêca, Diogo Vilar& Braga, Renan Marinho& Scotti, Marcus Tullius& do Nascimento, Terezinha Weyne Araújo Borges& Assis, Davidson Barbosa…[et al.]. 2019. 2-Allylphenol Reduces IL-1β and TNF-α, Promoting Antinociception through Adenosinergic, Anti-Inflammatory, and Antioxidant Mechanisms. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1202150
Modern Language Association (MLA)
Aragão Neto, Humberto de Carvalho…[et al.]. 2-Allylphenol Reduces IL-1β and TNF-α, Promoting Antinociception through Adenosinergic, Anti-Inflammatory, and Antioxidant Mechanisms. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1202150
American Medical Association (AMA)
Aragão Neto, Humberto de Carvalho& da Fonsêca, Diogo Vilar& Braga, Renan Marinho& Scotti, Marcus Tullius& do Nascimento, Terezinha Weyne Araújo Borges& Assis, Davidson Barbosa…[et al.]. 2-Allylphenol Reduces IL-1β and TNF-α, Promoting Antinociception through Adenosinergic, Anti-Inflammatory, and Antioxidant Mechanisms. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1202150
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202150