Study on the Multitarget Synergistic Effects of Kai-Xin-San against Alzheimer’s Disease Based on Systems Biology
Joint Authors
Guo, Sirui
Wang, Jiahong
Wang, Yunjia
Zhang, Ying
Bi, Kaishun
Zhang, Zhou
Li, Qing
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-31
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Kai-Xin-San (KXS), a classical Chinese traditional prescription, was widely applied in the treatment of Alzheimer’s disease (AD), while its functional mechanisms still remain unclear.
By using systems biology approaches at animal, cellular, and molecular levels, the improvement of KXS on cognitive impairment was achieved by inhibiting abnormal acetylcholinesterase.
The function on the nerve skeleton was performed by regulating the Tau phosphorylation pathway.
Its antioxidant, anti-inflammatory, and antiapoptotic effects by modulating the aberrant upregulation of ROS, proinflammatory factors, and apoptosis-related proteins in the brain were studied to reveal the synergistic therapeutic efficacy of KXS.
Then, formula dismantling in vitro indicated that ginseng was the principal herb, whereas three other herbs served adjuvant roles to achieve the best effect.
After that, the in vivo analysis of components into plasma and brain of AD rats showed that 8 of 23 components in blood and 4 of 10 components in brain were from ginseng, respectively, further verifying the principal status of ginseng and the synergistic effects of the formula.
Thus, the anti-AD effects of KXS were achieved by multitargets and multichannels.
The systems biology approaches presented here provide a novel way in traditional herbal medicine research.
American Psychological Association (APA)
Guo, Sirui& Wang, Jiahong& Wang, Yunjia& Zhang, Ying& Bi, Kaishun& Zhang, Zhou…[et al.]. 2019. Study on the Multitarget Synergistic Effects of Kai-Xin-San against Alzheimer’s Disease Based on Systems Biology. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1202325
Modern Language Association (MLA)
Guo, Sirui…[et al.]. Study on the Multitarget Synergistic Effects of Kai-Xin-San against Alzheimer’s Disease Based on Systems Biology. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1202325
American Medical Association (AMA)
Guo, Sirui& Wang, Jiahong& Wang, Yunjia& Zhang, Ying& Bi, Kaishun& Zhang, Zhou…[et al.]. Study on the Multitarget Synergistic Effects of Kai-Xin-San against Alzheimer’s Disease Based on Systems Biology. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1202325
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202325