CGRP Reduces Apoptosis of DRG Cells Induced by High-Glucose Oxidative Stress Injury through PI3KAKT Induction of Heme Oxygenase-1 and Nrf-2 Expression
Joint Authors
Liu, YaDong
Zhang, SiCong
Xue, Jun
Wei, ZhongQing
Ao, Ping
Shen, BaiXin
Ding, LiuCheng
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Dorsal root ganglion (DRG) neurons, which are sensitive to oxidative stress due to their anatomical and structural characteristics, play a complex role in the initiation and progression of diabetic bladder neuropathy.
We investigated the hypothesis that the antioxidant and antiapoptotic effects of CGRP may be partly related to the expression of Nrf2 and HO-1, via the phosphatidylinositol 3-kinase (PI3K)/AKT pathway, thus reducing apoptosis and oxidative stress responses.
This study shows that CGRP activates the PI3K/AKT pathway, thereby inducing increased expression of Nrf2 and HO-1 and resulting in the decrease of reactive oxygen species and malondialdehyde levels and reduced neuronal apoptosis.
These effects were suppressed by LY294002, an inhibitor of the PI3K/AKT pathway.
Therefore, regulation of Nrf2 and HO-1 expression by the PI3K/AKT pathway plays an important role in the regulation of the antioxidant and antiapoptotic responses in DRG cells in a high-glucose culture model.
American Psychological Association (APA)
Liu, YaDong& Zhang, SiCong& Xue, Jun& Wei, ZhongQing& Ao, Ping& Shen, BaiXin…[et al.]. 2019. CGRP Reduces Apoptosis of DRG Cells Induced by High-Glucose Oxidative Stress Injury through PI3KAKT Induction of Heme Oxygenase-1 and Nrf-2 Expression. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1202487
Modern Language Association (MLA)
Liu, YaDong…[et al.]. CGRP Reduces Apoptosis of DRG Cells Induced by High-Glucose Oxidative Stress Injury through PI3KAKT Induction of Heme Oxygenase-1 and Nrf-2 Expression. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1202487
American Medical Association (AMA)
Liu, YaDong& Zhang, SiCong& Xue, Jun& Wei, ZhongQing& Ao, Ping& Shen, BaiXin…[et al.]. CGRP Reduces Apoptosis of DRG Cells Induced by High-Glucose Oxidative Stress Injury through PI3KAKT Induction of Heme Oxygenase-1 and Nrf-2 Expression. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1202487
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202487