Hydrogen Sulfide: Emerging Role in Bladder, Kidney, and Prostate Malignancies
Joint Authors
Akbari, Masoud
Sogutdelen, Emrullah
Juriasingani, Smriti
Sener, Alp
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hydrogen sulfide (H2S) is the latest member of the gasotransmitter family and known to play essential roles in cancer pathophysiology.
H2S is produced endogenously and can be administered exogenously.
Recent studies showed that H2S in cancers has both pro- and antitumor roles.
Understanding the difference in the expression and localization of tissue-specific H2S-producing enzymes in healthy and cancer tissues allows us to develop tools for cancer diagnosis and treatment.
Urological malignancies are some of the most common cancers in both men and women, and their early detection is vital since advanced cancers are recurrent, metastatic, and often resistant to treatment.
This review summarizes the roles of H2S in cancer and looks at current studies investigating H2S activity and expression of H2S-producing enzymes in urinary cancers.
We specifically focused on urothelial carcinoma, renal cell carcinoma, and prostate cancer, as they form the majority of newly diagnosed urinary cancers.
Recent studies show that besides the physiological activity of H2S in cancer cells, there are patterns between the development and prognosis of urinary cancers and the expression of H2S-producing enzymes and indirectly the H2S levels.
Though controversial and not completely understood, studying the expression of H2S-producing enzymes in cancer tissue may represent an avenue for novel diagnostic and therapeutic strategies for addressing urological malignancies.
American Psychological Association (APA)
Akbari, Masoud& Sogutdelen, Emrullah& Juriasingani, Smriti& Sener, Alp. 2019. Hydrogen Sulfide: Emerging Role in Bladder, Kidney, and Prostate Malignancies. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1202633
Modern Language Association (MLA)
Akbari, Masoud…[et al.]. Hydrogen Sulfide: Emerging Role in Bladder, Kidney, and Prostate Malignancies. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1202633
American Medical Association (AMA)
Akbari, Masoud& Sogutdelen, Emrullah& Juriasingani, Smriti& Sener, Alp. Hydrogen Sulfide: Emerging Role in Bladder, Kidney, and Prostate Malignancies. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1202633
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202633