Noncanonical Roles of hα-syn (A53T) in the Pathogenesis of Parkinson’s Disease: Synaptic Pathology and Neuronal Aging
Joint Authors
Yin, Jie
Gao, Li-Ping
Jing, Yu-Hong
Wang, Qing-Jun
Chen, An-Di
Chen, Hai-Chao
Wang, Dong-Xin
Cai, Yi-Ting
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-21
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The motor and nonmotor symptoms of PD involve several brain regions.
However, whether α-syn pathology originating from the SNc can directly lead to the pathological changes in distant cerebral regions and induce PD-related symptoms remains unclear.
Here, AAV9-synapsin-mCherry-human SNCA (A53T) was injected into the unilateral SNc of mice.
Motor function and olfactory sensitivity were evaluated.
Our results showed that AAV9-synapsin-mCherry-human SNCA was continuously expressed in SNc.
The animals showed mild motor and olfactory dysfunction at 7 months after viral injection.
The pathology in SNc was characterized by the loss of dopaminergic neurons accompanied by ER stress.
In the striatum, hα-syn expression was high, CaMKβ-2 and NR2B expression decreased, and active synapses reduced.
In the olfactory bulb, hα-syn expression was high, and aging cells in the mitral layer increased.
The results suggested that hα-syn was transported in the striatum and OB along the nerve fibers that originated from the SNc and induced pathological changes in the distant cerebral regions, which contributed to the motor and nonmotor symptoms of PD.
American Psychological Association (APA)
Wang, Qing-Jun& Chen, An-Di& Chen, Hai-Chao& Wang, Dong-Xin& Cai, Yi-Ting& Yin, Jie…[et al.]. 2020. Noncanonical Roles of hα-syn (A53T) in the Pathogenesis of Parkinson’s Disease: Synaptic Pathology and Neuronal Aging. Neural Plasticity،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1202727
Modern Language Association (MLA)
Wang, Qing-Jun…[et al.]. Noncanonical Roles of hα-syn (A53T) in the Pathogenesis of Parkinson’s Disease: Synaptic Pathology and Neuronal Aging. Neural Plasticity No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1202727
American Medical Association (AMA)
Wang, Qing-Jun& Chen, An-Di& Chen, Hai-Chao& Wang, Dong-Xin& Cai, Yi-Ting& Yin, Jie…[et al.]. Noncanonical Roles of hα-syn (A53T) in the Pathogenesis of Parkinson’s Disease: Synaptic Pathology and Neuronal Aging. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1202727
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202727