Protective Effect of Dinitrosyl Iron Complexes with Glutathione in Red Blood Cell Lysis Induced by Hypochlorous Acid
Joint Authors
Cherenkevich, Sergey N.
Shumaev, Konstantin B.
Gorudko, Irina V.
Kosmachevskaya, Olga V.
Grigorieva, Daria V.
Panasenko, Оleg M.
Topunov, Alexey F.
Terekhova, Maria S.
Sokolov, Alexey V.
Ruuge, Enno K.
Vanin, Anatoly F.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Hypochlorous acid (HOCl), one of the major precursors of free radicals in body cells and tissues, is endowed with strong prooxidant activity.
In living systems, dinitrosyl iron complexes (DNIC) with glutathione ligands play the role of nitric oxide donors and possess a broad range of biological activities.
At micromolar concentrations, DNIC effectively inhibit HOCl-induced lysis of red blood cells (RBCs) and manifest an ability to scavenge alkoxyl and alkylperoxyl radicals generated in the reaction of HOCl with tert-butyl hydroperoxide.
DNIC proved to be more effective cytoprotective agents and organic free radical scavengers in comparison with reduced glutathione (GSH).
At the same time, the kinetics of HOCl-induced oxidation of glutathione ligands in DNIC is slower than in the case of GSH.
HOCl-induced oxidative conversions of thiolate ligands cause modification of DNIC, which manifests itself in inclusion of other ligands.
It is suggested that the strong inhibiting effect of DNIC with glutathione on HOCl-induced lysis of RBCs is determined by their antioxidant and regulatory properties.
American Psychological Association (APA)
Shumaev, Konstantin B.& Gorudko, Irina V.& Kosmachevskaya, Olga V.& Grigorieva, Daria V.& Panasenko, Оleg M.& Vanin, Anatoly F.…[et al.]. 2019. Protective Effect of Dinitrosyl Iron Complexes with Glutathione in Red Blood Cell Lysis Induced by Hypochlorous Acid. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1202938
Modern Language Association (MLA)
Shumaev, Konstantin B.…[et al.]. Protective Effect of Dinitrosyl Iron Complexes with Glutathione in Red Blood Cell Lysis Induced by Hypochlorous Acid. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1202938
American Medical Association (AMA)
Shumaev, Konstantin B.& Gorudko, Irina V.& Kosmachevskaya, Olga V.& Grigorieva, Daria V.& Panasenko, Оleg M.& Vanin, Anatoly F.…[et al.]. Protective Effect of Dinitrosyl Iron Complexes with Glutathione in Red Blood Cell Lysis Induced by Hypochlorous Acid. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1202938
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202938