Protective Effect of Dinitrosyl Iron Complexes with Glutathione in Red Blood Cell Lysis Induced by Hypochlorous Acid

Joint Authors

Cherenkevich, Sergey N.
Shumaev, Konstantin B.
Gorudko, Irina V.
Kosmachevskaya, Olga V.
Grigorieva, Daria V.
Panasenko, Оleg M.
Topunov, Alexey F.
Terekhova, Maria S.
Sokolov, Alexey V.
Ruuge, Enno K.
Vanin, Anatoly F.

Source

Oxidative Medicine and Cellular Longevity

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-04-08

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Biology

Abstract EN

Hypochlorous acid (HOCl), one of the major precursors of free radicals in body cells and tissues, is endowed with strong prooxidant activity.

In living systems, dinitrosyl iron complexes (DNIC) with glutathione ligands play the role of nitric oxide donors and possess a broad range of biological activities.

At micromolar concentrations, DNIC effectively inhibit HOCl-induced lysis of red blood cells (RBCs) and manifest an ability to scavenge alkoxyl and alkylperoxyl radicals generated in the reaction of HOCl with tert-butyl hydroperoxide.

DNIC proved to be more effective cytoprotective agents and organic free radical scavengers in comparison with reduced glutathione (GSH).

At the same time, the kinetics of HOCl-induced oxidation of glutathione ligands in DNIC is slower than in the case of GSH.

HOCl-induced oxidative conversions of thiolate ligands cause modification of DNIC, which manifests itself in inclusion of other ligands.

It is suggested that the strong inhibiting effect of DNIC with glutathione on HOCl-induced lysis of RBCs is determined by their antioxidant and regulatory properties.

American Psychological Association (APA)

Shumaev, Konstantin B.& Gorudko, Irina V.& Kosmachevskaya, Olga V.& Grigorieva, Daria V.& Panasenko, Оleg M.& Vanin, Anatoly F.…[et al.]. 2019. Protective Effect of Dinitrosyl Iron Complexes with Glutathione in Red Blood Cell Lysis Induced by Hypochlorous Acid. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1202938

Modern Language Association (MLA)

Shumaev, Konstantin B.…[et al.]. Protective Effect of Dinitrosyl Iron Complexes with Glutathione in Red Blood Cell Lysis Induced by Hypochlorous Acid. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1202938

American Medical Association (AMA)

Shumaev, Konstantin B.& Gorudko, Irina V.& Kosmachevskaya, Olga V.& Grigorieva, Daria V.& Panasenko, Оleg M.& Vanin, Anatoly F.…[et al.]. Protective Effect of Dinitrosyl Iron Complexes with Glutathione in Red Blood Cell Lysis Induced by Hypochlorous Acid. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1202938

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1202938