Functional Correlates of Action Observation of Gait in Patients with Parkinson’s Disease
Joint Authors
Bommarito, Giulia
Putzolu, Martina
Avanzino, Laura
Cosentino, Carola
Botta, Alessandro
Marchese, Roberta
Inglese, Matilde
Pelosin, Elisa
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Action observation (AO) relies on the mirror neuron system (MNS) and has been proposed as a rehabilitation tool in Parkinson’s disease (PD), in particular for gait disorder such as freezing of gait (FOG).
In this study, we aimed to explore the brain functional correlates of the observation of human gait in PD patients with (FOG+) and without (FOG-) FOG and to investigate a possible relationship between AO-induced brain activation and gait performance.
Methods.
Fifty-four participants were enrolled in the study (15 PD FOG+; 18 PD FOG-; 21 healthy subjects (HS)) which consisted of two tasks in two separate days: (i) gait assessment and (ii) task-fMRI during AO of gait.
Differences between patients with PD (FOG+ and FOG-) and HS were assessed at the level of behavioral and functional analysis.
Results.
Gait parameters, including gait velocity, stride length, and their coefficients of variability (CV), were different in PD patients compared to HS, whereas gait performance was similar between FOG+ and FOG-.
The PD group, compared to HS, presented reduced functional activation in the frontal, cingulum, and parietooccipital regions.
Reduced activity was more pronounced in the FOG+ group, compared to both HS and FOG- groups.
Gait variability positively correlated with precuneus neural activity in the FOG+ group.
Discussion.
Patients with PD present a reduced functional activity during AO of gait, especially if FOG+.
A baseline knowledge of the neural correlates of AO of gait in the clinical routine “on” status would help for the design of future AO rehabilitative interventions.
American Psychological Association (APA)
Bommarito, Giulia& Putzolu, Martina& Avanzino, Laura& Cosentino, Carola& Botta, Alessandro& Marchese, Roberta…[et al.]. 2020. Functional Correlates of Action Observation of Gait in Patients with Parkinson’s Disease. Neural Plasticity،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1203037
Modern Language Association (MLA)
Bommarito, Giulia…[et al.]. Functional Correlates of Action Observation of Gait in Patients with Parkinson’s Disease. Neural Plasticity No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1203037
American Medical Association (AMA)
Bommarito, Giulia& Putzolu, Martina& Avanzino, Laura& Cosentino, Carola& Botta, Alessandro& Marchese, Roberta…[et al.]. Functional Correlates of Action Observation of Gait in Patients with Parkinson’s Disease. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1203037
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203037