Stress-Sensitive Protein Rac1 and Its Involvement in Neurodevelopmental Disorders
Joint Authors
Wang, Xiaohui
Liu, Dongbin
Wei, Fangzhen
Li, Yue
Wang, Xuefeng
Li, Linjie
Wang, Guan
Zhang, Shuli
Zhang, Lei
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Ras-related C3 botulinum toxin substrate 1 (Rac1) is a small GTPase that is well known for its sensitivity to the environmental stress of a cell or an organism.
It senses the external signals which are transmitted from membrane-bound receptors and induces downstream signaling cascades to exert its physiological functions.
Rac1 is an important regulator of a variety of cellular processes, such as cytoskeletal organization, generation of oxidative products, and gene expression.
In particular, Rac1 has a significant influence on certain brain functions like neuronal migration, synaptic plasticity, and memory formation via regulation of actin dynamics in neurons.
Abnormal Rac1 expression and activity have been observed in multiple neurological diseases.
Here, we review recent findings to delineate the role of Rac1 signaling in neurodevelopmental disorders associated with abnormal spine morphology, synaptogenesis, and synaptic plasticity.
Moreover, certain novel inhibitors of Rac1 and related pathways are discussed as potential avenues toward future treatment for these diseases.
American Psychological Association (APA)
Wang, Xiaohui& Liu, Dongbin& Wei, Fangzhen& Li, Yue& Wang, Xuefeng& Li, Linjie…[et al.]. 2020. Stress-Sensitive Protein Rac1 and Its Involvement in Neurodevelopmental Disorders. Neural Plasticity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1203144
Modern Language Association (MLA)
Wang, Xiaohui…[et al.]. Stress-Sensitive Protein Rac1 and Its Involvement in Neurodevelopmental Disorders. Neural Plasticity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1203144
American Medical Association (AMA)
Wang, Xiaohui& Liu, Dongbin& Wei, Fangzhen& Li, Yue& Wang, Xuefeng& Li, Linjie…[et al.]. Stress-Sensitive Protein Rac1 and Its Involvement in Neurodevelopmental Disorders. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1203144
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203144