Alzheimer’s Disease as a Result of Stimulus Reduction in a GABA-A-Deficient Brain: A Neurocomputational Model
Joint Authors
Aguiar-Furucho, Mariana Antonia
Peláez, Francisco Javier Ropero
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-26, 26 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-14
Country of Publication
Egypt
No. of Pages
26
Main Subjects
Abstract EN
Several research studies point to the fact that sensory and cognitive reductions like cataracts, deafness, macular degeneration, or even lack of activity after job retirement, precede the onset of Alzheimer’s disease.
To simulate Alzheimer’s disease earlier stages, which manifest in sensory cortices, we used a computational model of the koniocortex that is the first cortical stage processing sensory information.
The architecture and physiology of the modeled koniocortex resemble those of its cerebral counterpart being capable of continuous learning.
This model allows one to analyze the initial phases of Alzheimer’s disease by “aging” the artificial koniocortex through synaptic pruning, by the modification of acetylcholine and GABA-A signaling, and by reducing sensory stimuli, among other processes.
The computational model shows that during aging, a GABA-A deficit followed by a reduction in sensory stimuli leads to a dysregulation of neural excitability, which in the biological brain is associated with hypermetabolism, one of the earliest symptoms of Alzheimer’s disease.
American Psychological Association (APA)
Aguiar-Furucho, Mariana Antonia& Peláez, Francisco Javier Ropero. 2020. Alzheimer’s Disease as a Result of Stimulus Reduction in a GABA-A-Deficient Brain: A Neurocomputational Model. Neural Plasticity،Vol. 2020, no. 2020, pp.1-26.
https://search.emarefa.net/detail/BIM-1203149
Modern Language Association (MLA)
Aguiar-Furucho, Mariana Antonia& Peláez, Francisco Javier Ropero. Alzheimer’s Disease as a Result of Stimulus Reduction in a GABA-A-Deficient Brain: A Neurocomputational Model. Neural Plasticity No. 2020 (2020), pp.1-26.
https://search.emarefa.net/detail/BIM-1203149
American Medical Association (AMA)
Aguiar-Furucho, Mariana Antonia& Peláez, Francisco Javier Ropero. Alzheimer’s Disease as a Result of Stimulus Reduction in a GABA-A-Deficient Brain: A Neurocomputational Model. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-26.
https://search.emarefa.net/detail/BIM-1203149
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203149