Dexmedetomidine Inhibits Voltage-Gated Sodium Channels via α2-Adrenoceptors in Trigeminal Ganglion Neurons
Joint Authors
Park, Chul-Kyu
Im, Sang-Taek
Jo, Youn Yi
Han, Gayoung
Jo, Hyun Jung
Kim, Yong Ho
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Dexmedetomidine, an α2-adrenoceptor agonist, is widely used as a sedative and analgesic agent in a number of clinical applications.
However, little is known about the mechanism by which it exerts its analgesic effects on the trigeminal system.
Two types of voltage-gated sodium channels, Nav1.7 and Nav1.8, as well as α2-adrenoceptors are expressed in primary sensory neurons of the trigeminal ganglion (TG).
Using whole-cell patch-clamp recordings, we investigated the effects of dexmedetomidine on voltage-gated sodium channel currents (INa) via α2-adrenoceptors in dissociated, small-sized TG neurons.
Dexmedetomidine caused a concentration-dependent inhibition of INa in small-sized TG neurons.
INa inhibition by dexmedetomidine was blocked by yohimbine, a competitive α2-adrenoceptor antagonist.
Dexmedetomidine-induced inhibition of INa was mediated by G protein-coupled receptors (GPCRs) as this effect was blocked by intracellular perfusion with the G protein inhibitor GDPβ-S.
Our results suggest that the INa inhibition in small-sized TG neurons, mediated by the activation of Gi/o protein-coupled α2-adrenoceptors, might contribute to the analgesic effects of dexmedetomidine in the trigeminal system.
Therefore, these new findings highlight a potential novel target for analgesic drugs in the orofacial region.
American Psychological Association (APA)
Im, Sang-Taek& Jo, Youn Yi& Han, Gayoung& Jo, Hyun Jung& Kim, Yong Ho& Park, Chul-Kyu. 2018. Dexmedetomidine Inhibits Voltage-Gated Sodium Channels via α2-Adrenoceptors in Trigeminal Ganglion Neurons. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1203365
Modern Language Association (MLA)
Im, Sang-Taek…[et al.]. Dexmedetomidine Inhibits Voltage-Gated Sodium Channels via α2-Adrenoceptors in Trigeminal Ganglion Neurons. Mediators of Inflammation No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1203365
American Medical Association (AMA)
Im, Sang-Taek& Jo, Youn Yi& Han, Gayoung& Jo, Hyun Jung& Kim, Yong Ho& Park, Chul-Kyu. Dexmedetomidine Inhibits Voltage-Gated Sodium Channels via α2-Adrenoceptors in Trigeminal Ganglion Neurons. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1203365
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203365