Prevention of Huntington’s Disease-Like Behavioral Deficits in R61 Mouse by Tolfenamic Acid Is Associated with Decreases in Mutant Huntingtin and Oxidative Stress
Joint Authors
Ji, Xue-Fei
Chi, Tian-Yan
Zou, Li-Bo
Li, Lin
Liu, Peng
Li, Yinjie
Yang, Wei
Liu, Danyang
Guo, Zhutao
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Tolfenamic acid is a nonsteroidal anti-inflammatory drug with neuroprotective properties, and it alleviates learning and memory deficits in the APP transgenic mouse model of Alzheimer’s disease.
However, whether tolfenamic acid can prevent motor and memory dysfunction in transgenic animal models of Huntington’s disease (HD) remains unclear.
To this end, tolfenamic acid was orally administered to transgenic R6/1 mice from 10 to 20 weeks of age, followed by several behavioral tests to evaluate motor and memory function.
Tolfenamic acid improved motor coordination in R6/1 mice as tested by rotarod, grip strength, and locomotor behavior tests and attenuated memory dysfunction as analyzed using the novel object recognition test and passive avoidance test.
Tolfenamic acid decreased the expression of mutant huntingtin in the striatum of 20-week-old R6/1 mice by inhibiting specificity protein 1 expression and enhancing autophagic function.
Furthermore, tolfenamic acid exhibited antioxidant effects in both R6/1 mice and PC12 cell models.
Collectively, these results suggest that tolfenamic acid has a good therapeutic effect on R6/1 mice, and may be a potentially useful agent in the treatment of HD.
American Psychological Association (APA)
Liu, Peng& Li, Yinjie& Yang, Wei& Liu, Danyang& Ji, Xue-Fei& Chi, Tian-Yan…[et al.]. 2019. Prevention of Huntington’s Disease-Like Behavioral Deficits in R61 Mouse by Tolfenamic Acid Is Associated with Decreases in Mutant Huntingtin and Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1203485
Modern Language Association (MLA)
Liu, Peng…[et al.]. Prevention of Huntington’s Disease-Like Behavioral Deficits in R61 Mouse by Tolfenamic Acid Is Associated with Decreases in Mutant Huntingtin and Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1203485
American Medical Association (AMA)
Liu, Peng& Li, Yinjie& Yang, Wei& Liu, Danyang& Ji, Xue-Fei& Chi, Tian-Yan…[et al.]. Prevention of Huntington’s Disease-Like Behavioral Deficits in R61 Mouse by Tolfenamic Acid Is Associated with Decreases in Mutant Huntingtin and Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1203485
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203485