Anti-TNF-α Therapy Suppresses Proinflammatory Activities of Mucosal Neutrophils in Inflammatory Bowel Disease
Joint Authors
Liu, Zhanju
Zhou, Guangxi
Shu, Weigang
Lin, Jian
Zhang, Cui
Chu, Feifei
Wu, Huili
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Neutrophils have been found to play an important role in the pathogenesis of inflammatory bowel disease (IBD), and anti-TNF-α mAb (i.e., infliximab) therapy is demonstrated to be effective in the induction of clinical remission and mucosal healing in these patients.
However, how anti-TNF-α mAb regulates the functions of neutrophils is still unknown.
Herein, we found that anti-TNF-α therapy significantly downregulated infiltration of neutrophils in inflamed mucosa of IBD patients.
Importantly, anti-TNF-α mAb could inhibit neutrophils to produce proinflammatory mediators, such as ROS, calprotectin, IL-8, IL-6, and TNF-α.
These data indicate that TNF-α plays a critical role in the induction of mucosal inflammatory response, and that blockade of TNF-α modulates intestinal homeostasis through balancing immune responses of neutrophils.
American Psychological Association (APA)
Zhang, Cui& Shu, Weigang& Zhou, Guangxi& Lin, Jian& Chu, Feifei& Wu, Huili…[et al.]. 2018. Anti-TNF-α Therapy Suppresses Proinflammatory Activities of Mucosal Neutrophils in Inflammatory Bowel Disease. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1203501
Modern Language Association (MLA)
Zhang, Cui…[et al.]. Anti-TNF-α Therapy Suppresses Proinflammatory Activities of Mucosal Neutrophils in Inflammatory Bowel Disease. Mediators of Inflammation No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1203501
American Medical Association (AMA)
Zhang, Cui& Shu, Weigang& Zhou, Guangxi& Lin, Jian& Chu, Feifei& Wu, Huili…[et al.]. Anti-TNF-α Therapy Suppresses Proinflammatory Activities of Mucosal Neutrophils in Inflammatory Bowel Disease. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1203501
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203501