Natural Sesquiterpene Lactones Enhance Chemosensitivity of Tumor Cells through Redox Regulation of STAT3 Signaling
Joint Authors
Butturini, Elena
Carcereri de Prati, Alessandra
Boriero, Diana
Mariotto, Sofia
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-28
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
STAT3 is a nuclear transcription factor that regulates genes involved in cell cycle, cell survival, and immune response.
Although STAT3 activation drives cells to physiological response, its deregulation is often associated with the development and progression of many solid and hematological tumors as well as with drug resistance.
STAT3 is a redox-sensitive protein, and its activation state is related to intracellular GSH levels.
Under oxidative conditions, STAT3 activity is regulated by S-glutathionylation, a reversible posttranslational modification of cysteine residues.
Compounds able to suppress STAT3 activation and, on the other hand, to modulate intracellular redox homeostasis may potentially improve cancer treatment outcome.
Nowadays, about 35% of commercial drugs are natural compounds that derive from plant extracts used in phytotherapy and traditional medicine.
Sesquiterpene lactones are an interesting chemical group of plant-derived compounds often employed in traditional medicine against inflammation and cancer.
This review focuses on sesquiterpene lactones able to downmodulate STAT3 signaling leading to an antitumor effect and correlates the anti-STAT3 activity with their ability to decrease GSH levels in cancer cells.
These properties make them lead compounds for the development of a new therapeutic strategy for cancer treatment.
American Psychological Association (APA)
Butturini, Elena& Carcereri de Prati, Alessandra& Boriero, Diana& Mariotto, Sofia. 2019. Natural Sesquiterpene Lactones Enhance Chemosensitivity of Tumor Cells through Redox Regulation of STAT3 Signaling. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1203645
Modern Language Association (MLA)
Butturini, Elena…[et al.]. Natural Sesquiterpene Lactones Enhance Chemosensitivity of Tumor Cells through Redox Regulation of STAT3 Signaling. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1203645
American Medical Association (AMA)
Butturini, Elena& Carcereri de Prati, Alessandra& Boriero, Diana& Mariotto, Sofia. Natural Sesquiterpene Lactones Enhance Chemosensitivity of Tumor Cells through Redox Regulation of STAT3 Signaling. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1203645
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203645