Iron Redox Chemistry and Implications in the Parkinson’s Disease Brain
Joint Authors
Abeyawardhane, Dinendra L.
Lucas, Heather R.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The etiology of Parkinson’s disease (PD) is linked with cellular inclusions in the substantia nigra pars compacta region of the brain that are enriched in the misfolded presynaptic protein α-synuclein (αS) and death of the dopaminergic neurons.
Brain iron homeostasis governs both neurotransmission and neurodegeneration; hence, the role of iron in PD progression and neuronal health is apparent.
Elevated iron deposits become prevalent in the cerebral region upon aging and even more so in the PD brain.
Structural as well as oxidative modifications can result from coordination of αS with redox active iron, which could have functional and/or pathological implications.
In this review, we will discuss iron-mediated αS aggregation, alterations in iron metabolism, and the role of the iron-dopamine couple.
Moreover, iron interactions with N-terminally acetylated αS, the physiologically relevant form of the human protein, will be addressed to shed light on the current understanding of protein dynamics and the physiological environment in the disease state.
Oxidative pathways and biochemical alterations resulting from aberrant iron-induced chemistry are the principal focus of this review in order to highlight the plethora of research that has uncovered this emerging dichotomy of iron playing both functional and disruptive roles in PD pathology.
American Psychological Association (APA)
Abeyawardhane, Dinendra L.& Lucas, Heather R.. 2019. Iron Redox Chemistry and Implications in the Parkinson’s Disease Brain. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1203739
Modern Language Association (MLA)
Abeyawardhane, Dinendra L.& Lucas, Heather R.. Iron Redox Chemistry and Implications in the Parkinson’s Disease Brain. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1203739
American Medical Association (AMA)
Abeyawardhane, Dinendra L.& Lucas, Heather R.. Iron Redox Chemistry and Implications in the Parkinson’s Disease Brain. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1203739
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203739