IL-1RN and IL-1β Polymorphism and ARV-Associated Hepatotoxicity
Joint Authors
Singh, HariOm
Samani, Dharmesh
Nema, Vijay
Ghate, M.
Gangakhedkar, R.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-08
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The severity of hepatic injury depends upon cytokines.
Previous studies associated IL-1RN allele 2 with IL-1β production.
Hence, we examined the association of IL-1 RN and IL-1β polymorphisms with ARV-associated hepatotoxicity.
Genotyping of IL-1RN (VNTR), IL-1β (-511C/T) polymorphisms was done in 162 HIV-infected patients, 34 with ARV hepatotoxicity, 128 without hepatotoxicity, and 152 healthy controls using PCR and PCR-RFLP method.
The haplotypes 1T and 2C enhanced the risk for severe hepatotoxicity (OR=1.41, P=0.25; OR=1.67, P=0.31).
IL-1β-511TT genotype significantly represented among tobacco using HIV-infected individuals compared to nonusers (OR=3.74, P=0.05).
IL-1β-511TT genotype among alcohol users increased the risk for hepatotoxicity (OR=1.80, P=0.90).
IL-1β-511CT and -511TT genotypes overrepresented in alcohol using HIV-infected individuals (OR=2.29, P=0.27; OR=2.64, P=0.19).
IL-RN 2/2 and 1/3 genotypes represented higher in nevirapine using hepatotoxicity patients (OR=1.42, P=0.64, OR=8.79, P=0.09).
IL-1β-511CT and -511 TT genotypes among nevirapine users enhanced the risk for severe hepatotoxicity (OR=4.29, P=0.20; OR=1.95, P=0.56).
IL-1β-511CT and -511TT genotypes were overrepresented in combined nevirapine and alcohol using HIV-infected individuals as compared to nevirapine users and alcohol nonusers (OR=2.56, P=0.26; OR=2.84, P=0.24).
IL-1β-511TT genotype with tobacco, alcohol, and nevirapine usage revealed a trend of risk for the development of ARV-associated hepatotoxicity and its severity.
American Psychological Association (APA)
Singh, HariOm& Samani, Dharmesh& Nema, Vijay& Ghate, M.& Gangakhedkar, R.. 2018. IL-1RN and IL-1β Polymorphism and ARV-Associated Hepatotoxicity. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1203765
Modern Language Association (MLA)
Singh, HariOm…[et al.]. IL-1RN and IL-1β Polymorphism and ARV-Associated Hepatotoxicity. Mediators of Inflammation No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1203765
American Medical Association (AMA)
Singh, HariOm& Samani, Dharmesh& Nema, Vijay& Ghate, M.& Gangakhedkar, R.. IL-1RN and IL-1β Polymorphism and ARV-Associated Hepatotoxicity. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1203765
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203765