Glutathione “Redox Homeostasis” and Its Relation to Cardiovascular Disease
Joint Authors
Bajic, Vladimir
Zafirovic, Sonja
Isenovic, Esma R.
Essack, Magbubah
Van Neste, Christophe
Bajic, Vladan P.
Obradovic, Milan
Radak, Djordje
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-09
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
More people die from cardiovascular diseases (CVD) than from any other cause.
Cardiovascular complications are thought to arise from enhanced levels of free radicals causing impaired “redox homeostasis,” which represents the interplay between oxidative stress (OS) and reductive stress (RS).
In this review, we compile several experimental research findings that show sustained shifts towards OS will alter the homeostatic redox mechanism to cause cardiovascular complications, as well as findings that show a prolonged antioxidant state or RS can similarly lead to such cardiovascular complications.
This experimental evidence is specifically focused on the role of glutathione, the most abundant antioxidant in the heart, in a redox homeostatic mechanism that has been shifted towards OS or RS.
This may lead to impairment of cellular signaling mechanisms and elevated pools of proteotoxicity associated with cardiac dysfunction.
American Psychological Association (APA)
Bajic, Vladan P.& Van Neste, Christophe& Obradovic, Milan& Zafirovic, Sonja& Radak, Djordje& Bajic, Vladimir…[et al.]. 2019. Glutathione “Redox Homeostasis” and Its Relation to Cardiovascular Disease. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1203899
Modern Language Association (MLA)
Bajic, Vladan P.…[et al.]. Glutathione “Redox Homeostasis” and Its Relation to Cardiovascular Disease. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1203899
American Medical Association (AMA)
Bajic, Vladan P.& Van Neste, Christophe& Obradovic, Milan& Zafirovic, Sonja& Radak, Djordje& Bajic, Vladimir…[et al.]. Glutathione “Redox Homeostasis” and Its Relation to Cardiovascular Disease. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1203899
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203899