Neuroglobin Expression Models as a Tool to Study Its Function
Joint Authors
Luyckx, Evi
Van Acker, Zoë P.
Ponsaerts, Peter
Dewilde, Sylvia
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-19
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Neuroglobin (Ngb) is an evolutionary conserved member of the globin family with a primary expression in neurons of which the exact functions remain elusive.
A plethora of in vivo and in vitro model systems has been generated to this day to determine the functional biological roles of Ngb.
Here, we provide a comprehensive overview and discussion of the different Ngb models, covering animal and cellular models of both overexpression and knockout strategies.
Intriguingly, an in-depth literature search of available Ngb expression models revealed crucial discrepancies in the outcomes observed in different models.
Not only does the level of Ngb expression—either physiologically, overexpressed, or downregulated—alter its functional properties, the experimental setup, being in vitro or in vivo, does impact the functional outcome as well and, hence, whether or not a physiological and/or therapeutic role is ascribed to Ngb.
These differences could highlight either technical or biological adaptations and should be considered until elucidation of the Ngb biology.
American Psychological Association (APA)
Luyckx, Evi& Van Acker, Zoë P.& Ponsaerts, Peter& Dewilde, Sylvia. 2019. Neuroglobin Expression Models as a Tool to Study Its Function. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1204250
Modern Language Association (MLA)
Luyckx, Evi…[et al.]. Neuroglobin Expression Models as a Tool to Study Its Function. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-17.
https://search.emarefa.net/detail/BIM-1204250
American Medical Association (AMA)
Luyckx, Evi& Van Acker, Zoë P.& Ponsaerts, Peter& Dewilde, Sylvia. Neuroglobin Expression Models as a Tool to Study Its Function. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1204250
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204250