Tabetri™ (Tabebuia avellanedae Ethanol Extract) Ameliorates Atopic Dermatitis Symptoms in Mice
Joint Authors
Yi, Young-Su
Kim, Eunji
Kim, Jong-Hoon
Han, Sang Yun
Baik, Kwang Soo
Choi, Su Young
Hong, Yo Han
Yoo, Sulgi
Jeong, Seong-Gu
Aravinthan, Adithan
Kim, Jung-Il
Cho, Jae Youl
Park, Jae Gwang
Son, Young-Jin
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Tabebuia avellanedae has been traditionally used as an herbal remedy to alleviate various diseases.
However, the plant’s pharmacological activity in allergic and inflammatory diseases and its underlying mechanism are not fully understood.
Therefore, we investigated the pharmacological activity of Tabetri (T.
avellanedae ethanol extract (Ta-EE)) in the pathogenesis of AD.
Its underlying mechanism was explored using an AD mouse model and splenocytes isolated from this model.
Ta-EE ameliorated the AD symptoms without any toxicity and protected the skin of 2,4-dinitrochlorobenzene- (DNCB-) induced AD mice from damage and epidermal thickness.
Ta-EE reduced the secreted levels of allergic and proinflammatory cytokines, including histamine, immunoglobulin E (IgE), interleukin- (IL-) 4, and interferon-gamma (IFN-γ) in the DNCB-induced AD mice.
Ta-EE suppressed the mRNA expression of T helper 2-specific cytokines, IL-4 and IL-5, and the proinflammatory cytokine IFN-γ in the atopic dermatitis skin lesions of AD mice.
Moreover, Ta-EE suppressed the mRNA expression of IL-4, IL-5, IFN-γ, and another proinflammatory cytokine, IL-12, in the Con A-stimulated splenocytes.
It also suppressed IL-12 and IFN-γ in the LPS-stimulated splenocytes.
Taken together, these results suggest that Ta-EE protects against the development of AD through the inhibition of mRNA expression of T helper 2-specific cytokines and other proinflammatory cytokines.
American Psychological Association (APA)
Park, Jae Gwang& Yi, Young-Su& Han, Sang Yun& Hong, Yo Han& Yoo, Sulgi& Kim, Eunji…[et al.]. 2018. Tabetri™ (Tabebuia avellanedae Ethanol Extract) Ameliorates Atopic Dermatitis Symptoms in Mice. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1204401
Modern Language Association (MLA)
Park, Jae Gwang…[et al.]. Tabetri™ (Tabebuia avellanedae Ethanol Extract) Ameliorates Atopic Dermatitis Symptoms in Mice. Mediators of Inflammation No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1204401
American Medical Association (AMA)
Park, Jae Gwang& Yi, Young-Su& Han, Sang Yun& Hong, Yo Han& Yoo, Sulgi& Kim, Eunji…[et al.]. Tabetri™ (Tabebuia avellanedae Ethanol Extract) Ameliorates Atopic Dermatitis Symptoms in Mice. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1204401
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204401