Spotlight on ROS and β3-Adrenoreceptors Fighting in Cancer Cells
Joint Authors
Calvani, Maura
Subbiani, Angela
Vignoli, Marina
Favre, Claudio
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-16
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The role of ROS and RNS is a long-standing debate in cancer.
Increasing the concentration of ROS reaching the toxic threshold can be an effective strategy for the reduction of tumor cell viability.
On the other hand, cancer cells, by maintaining intracellular ROS concentration at an intermediate level called “mild oxidative stress,” promote the activation of signaling that favors tumor progression by increasing cell viability and dangerous tumor phenotype.
Many chemotherapeutic treatments induce cell death by rising intracellular ROS concentration.
The persistent drug stimulation leads tumor cells to simulate a process called hormesis by which cancer cells exhibit a biphasic response to exposure to drugs used.
After a first strong response to a low dose of chemotherapeutic agent, cancer cells start to decrease the response even if high doses of drugs were used.
In this framework, β3-adrenoreceptors (β3-ARs) fit with an emerging antioxidant role in cancer.
β3-ARs are involved in tumor proliferation, angiogenesis, metastasis, and immune tolerance.
Its inhibition, by the selective β3-ARs antagonist (SR59230A), leads cancer cells to increase ROS concentration thus inducing cell death and to decrease NO levels thus inhibiting angiogenesis.
In this review, we report an overview on reactive oxygen biology in cancer cells focusing on β3-ARs as new players in the antioxidant pathway.
American Psychological Association (APA)
Calvani, Maura& Subbiani, Angela& Vignoli, Marina& Favre, Claudio. 2019. Spotlight on ROS and β3-Adrenoreceptors Fighting in Cancer Cells. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1204562
Modern Language Association (MLA)
Calvani, Maura…[et al.]. Spotlight on ROS and β3-Adrenoreceptors Fighting in Cancer Cells. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1204562
American Medical Association (AMA)
Calvani, Maura& Subbiani, Angela& Vignoli, Marina& Favre, Claudio. Spotlight on ROS and β3-Adrenoreceptors Fighting in Cancer Cells. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1204562
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204562