Effects of Angiotensin-(1-7) and Angiotensin II on Acetylcholine-Induced Vascular Relaxation in Spontaneously Hypertensive Rats
Joint Authors
Zhang, Feng
Xu, Yu
Pan, Yan
Sun, Shuo
Chen, Aidong
Li, Peng
Bao, Changlei
Wang, Jian
Tang, Haiyang
Han, Ying
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Endothelial dysfunction of small arteries occurs in patients with hypertension and in various hypertensive models.
Endothelial function is usually evaluated by the degree of acetylcholine- (ACh-) induced vascular relaxation.
Our previous study has found that compared to Wistar-Kyoto rats (WKY), ACh-induced vasodilatation was attenuated significantly in the mesenteric artery (MA), coronary artery (CA), and pulmonary artery (PA) of spontaneously hypertensive rats (SHR).
This study investigated the influence of angiotensin- (Ang-) (1-7) and Ang II on blood pressure and ACh-induced vascular relaxation, as well as their interactive roles and downstream signal pathways in SHR and WKY.
Intravenous injection of Ang II significantly increased, while Ang-(1-7) decreased the mean arterial pressure (MAP) in SHR.
Ang-(1-7) improved ACh-induced relaxation in the MA, CA, and PA of SHR, while Ang II further attenuated it, which were inhibited by pretreatment with Mas receptor antagonist A-779 or AT1 receptor antagonist losartan, respectively.
Ang-(1-7) decreased the basal arterial tension, and Ang II induced great vasoconstriction in SHR.
Pretreatment with Ang-(1-7) inhibited the Ang II-induced pressor response, vasoconstriction, and the effects on ACh-induced relaxation in SHR.
AT1 receptor expression was higher, while nitric oxide (NO), cGMP, and protein kinase G (PKG) levels of arteries were lower in SHR than in WKY.
Ang II decreased, while Ang-(1-7) increased, the levels of NO, cGMP, and PKG of arteries.
In addition, pretreatment with Ang-(1-7) inhibited the Ang II-induced reduction of NO, cGMP, and PKG in SHR.
These results indicate that the activation of the Mas receptor by Ang-(1-7) can improve endothelial function and decrease MAP in SHR and inhibit the deteriorative effect of Ang II on endothelial function through the NO-cGMP-PKG pathway.
American Psychological Association (APA)
Zhang, Feng& Xu, Yu& Pan, Yan& Sun, Shuo& Chen, Aidong& Li, Peng…[et al.]. 2019. Effects of Angiotensin-(1-7) and Angiotensin II on Acetylcholine-Induced Vascular Relaxation in Spontaneously Hypertensive Rats. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1204694
Modern Language Association (MLA)
Zhang, Feng…[et al.]. Effects of Angiotensin-(1-7) and Angiotensin II on Acetylcholine-Induced Vascular Relaxation in Spontaneously Hypertensive Rats. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1204694
American Medical Association (AMA)
Zhang, Feng& Xu, Yu& Pan, Yan& Sun, Shuo& Chen, Aidong& Li, Peng…[et al.]. Effects of Angiotensin-(1-7) and Angiotensin II on Acetylcholine-Induced Vascular Relaxation in Spontaneously Hypertensive Rats. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1204694
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204694