Deuterium Incorporation Protects Cells from Oxidative Damage
Joint Authors
Fimognari, Carmela
Turrini, Eleonora
Calcabrini, Cinzia
Brigotti, Maurizio
Arfilli, Valentina
Carnicelli, Domenica
Lucarini, Marco
Mazzanti, Andrea
Milelli, Andrea
Righi, Valeria
Sestili, Piero
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
In the cold environments of the interstellar medium, a variety of molecules in which a hydrogen (H) atom has been replaced by its heavier isotope deuterium (D) can be found.
From its emergence, life had to counteract the toxic action of many agents, which posed a constant threat to its development and propagation.
Oxygen-reactive species are archaic toxicants that lead to protein damage and genomic instability.
Most of the oxidative lesions involve cleavage of C-H bonds and H abstraction.
According to free radical chemistry principles, the substitution of D for H in oxidation-sensitive positions of cellular components should confer protection against the oxidative attack without compromising the chemical identity of the compounds.
Here, we show that deuterated nucleosides and proteins protect from oxidative damage.
Our data suggest a new, subtle but likely role of D in terrestrial life’s evolution in that its inclusion in critical biomolecules might have facilitated their resistance during the infinite generations of life entities, cells, and organisms.
American Psychological Association (APA)
Sestili, Piero& Brigotti, Maurizio& Calcabrini, Cinzia& Turrini, Eleonora& Arfilli, Valentina& Carnicelli, Domenica…[et al.]. 2019. Deuterium Incorporation Protects Cells from Oxidative Damage. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1204705
Modern Language Association (MLA)
Sestili, Piero…[et al.]. Deuterium Incorporation Protects Cells from Oxidative Damage. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1204705
American Medical Association (AMA)
Sestili, Piero& Brigotti, Maurizio& Calcabrini, Cinzia& Turrini, Eleonora& Arfilli, Valentina& Carnicelli, Domenica…[et al.]. Deuterium Incorporation Protects Cells from Oxidative Damage. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1204705
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204705