Shepherd’s Purse Polyphenols Exert Its Anti-Inflammatory and Antioxidative Effects Associated with Suppressing MAPK and NF-κB Pathways and Heme Oxygenase-1 Activation
Joint Authors
Peng, Jinming
Hu, Tianyong
Li, Jin
Du, Jing
Zhu, Kerui
Cheng, Baohui
Li, Kaikai
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-13
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Shepherd’s purse (Capsella bursa-pastoris (L.) Medik.), a wild herb as a traditional herbal medicine, has been proved with multiple healthy benefits.
In this study, the chemical constituents of shepherd’s purse were identified by UPLC-QTOF-MS/MS.
The antioxidative and anti-inflammatory potential of shepherd’s purse extract (SPE) were also investigated applying lipopolysaccharide- (LPS-) induced inflammation in RAW 264.7 macrophages and a carrageenan-induced mice paw edema model.
Twenty-four chemical compounds were identified mainly including phenolic acids and flavonoids.
The data also indicated SPE inhibited the productions of NO, PGE2, TNF-α, and IL-6 stimulated with LPS.
In addition, SPE inhibited the increase of reactive oxygen species (ROS) and upregulated the expression of heme oxygenase-1 (HO-1).
We further found that SPE inhibited the phosphorylation of P38 MAPK and activation of NF-κB.
In vivo mice model also indicated that SPE showed strong antioxidative and anti-inflammatory activity.
American Psychological Association (APA)
Peng, Jinming& Hu, Tianyong& Li, Jin& Du, Jing& Zhu, Kerui& Cheng, Baohui…[et al.]. 2019. Shepherd’s Purse Polyphenols Exert Its Anti-Inflammatory and Antioxidative Effects Associated with Suppressing MAPK and NF-κB Pathways and Heme Oxygenase-1 Activation. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1205043
Modern Language Association (MLA)
Peng, Jinming…[et al.]. Shepherd’s Purse Polyphenols Exert Its Anti-Inflammatory and Antioxidative Effects Associated with Suppressing MAPK and NF-κB Pathways and Heme Oxygenase-1 Activation. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1205043
American Medical Association (AMA)
Peng, Jinming& Hu, Tianyong& Li, Jin& Du, Jing& Zhu, Kerui& Cheng, Baohui…[et al.]. Shepherd’s Purse Polyphenols Exert Its Anti-Inflammatory and Antioxidative Effects Associated with Suppressing MAPK and NF-κB Pathways and Heme Oxygenase-1 Activation. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1205043
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205043