Mild Oxidative Stress Reduces NRF2 SUMOylation to Promote KrasLkb1Keap1 Mutant Lung Adenocarcinoma Cell Migration and Invasion
Joint Authors
Guo, Haoyan
Zhang, Wenlong
Xu, Jiaqian
Xing, Zhengcao
He, Jianli
Cheng, Jinke
Cai, Rong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Nuclear factor erythroid 2-related factor 2 (NRF2) is a crucial transcription factor for cell adaptation and defense against oxidative stress.
NRF2 activation confers Kras/Lkb1/Keap1 (KLK) mutant tumor cells with greater resistance to oxidative insults.
We previously reported that SUMOylation at lysine residue 110 is important for the ability of NRF2 to promote reactive oxygen species (ROS) clearance in hepatocellular carcinoma.
In this study, we investigated whether SUMOylation is necessary for the ability of NRF2 to inhibit KLK lung adenocarcinoma (LUAD) cell migration and invasion.
Our experiments showed that mild oxidative stress reduced NRF2 SUMOylation, which promoted KLK LUAD cell migration and invasion.
Mechanistically, NRF2 SUMOylation increased the antioxidant ability of NRF2 and reduced cellular ROS levels, mainly by transcriptionally activating Cat in KLK LUAD cells.
With reduced NRF2 SUMOylation, increased ROS acted as signaling molecules to activate the JNK/c-Jun axis, which enhanced cell mobility and cell adhesion, to promote LUAD cell migration and invasion.
Taken together, the results of this study reveal a novel signaling process in which reduced NRF2 SUMOylation permits increased KLK LUAD cell migration and invasion under mild oxidative stress.
American Psychological Association (APA)
Xu, Jiaqian& Guo, Haoyan& Xing, Zhengcao& Zhang, Wenlong& He, Jianli& Cheng, Jinke…[et al.]. 2020. Mild Oxidative Stress Reduces NRF2 SUMOylation to Promote KrasLkb1Keap1 Mutant Lung Adenocarcinoma Cell Migration and Invasion. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205083
Modern Language Association (MLA)
Xu, Jiaqian…[et al.]. Mild Oxidative Stress Reduces NRF2 SUMOylation to Promote KrasLkb1Keap1 Mutant Lung Adenocarcinoma Cell Migration and Invasion. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1205083
American Medical Association (AMA)
Xu, Jiaqian& Guo, Haoyan& Xing, Zhengcao& Zhang, Wenlong& He, Jianli& Cheng, Jinke…[et al.]. Mild Oxidative Stress Reduces NRF2 SUMOylation to Promote KrasLkb1Keap1 Mutant Lung Adenocarcinoma Cell Migration and Invasion. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205083
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205083