Overexpression of Inducible Nitric Oxide Synthase in Allergic and Nonallergic Nasal Polyp
Joint Authors
Eid, Safaa Yehia
El-Readi, Mahmoud Zaki
Althubiti, Mohammad Ahmad
Sadek, Ahmed Adel
Abdelwahab, Soha
Almaimani, Riyad A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Sinonasal polyps are very common benign lesions of the nasal mucosa.
Most of nasal polyps (NP) are idiopathic, and the pathophysiology of this disease is still incompletely understood.
Nitric oxide (NO) is a reactive molecule generated by nitric oxide synthase (NOS).
NO has been identified as an important mediator in airway function and pathogenesis of several respiratory system diseases.
Histological and genetical expression of iNOS was detected to evaluate the role of NO in the pathogenesis of allergic (ANP) and nonallergic nasal polyps (NANP).
Forty patients with nasal polyps (20 allergic and 20 nonallergic) were identified by history, clinical examination, and investigation.
NPs were obtained from the middle turbinate (MT) during concha bullosa surgery.
Twenty normal MT nasal tissues were taken as the control from patients undergoing concha bullosa surgery, without any evidence of allergy or inflammation.
A nasal polyp specimen from each patient was subjected for immune-histochemical study followed by histological examination to detect the expression of iNOS.
RT-PCR was used to evaluate the iNOS gene expression in isolated tissues.
The expression of iNOS in both epithelial and stromal layers was greater in NP than in MT tissues.
The ANP group showed more iNOS expression than those of the NANP group.
The relative mRNA levels of iNOS gene were significantly higher in ANP (2.5-fold) compared to the normal (1.02-fold, P<0.001) and NANP (1.5-fold, P<0.01) groups.
NP exhibited a significantly high expression of iNOS at both histological and genetical levels.
NO might be an essential factor in the life history of NP.
Further studies in a larger sample size are required to explain the probable mechanisms of NO in pathogenesis of NP.
American Psychological Association (APA)
Sadek, Ahmed Adel& Abdelwahab, Soha& Eid, Safaa Yehia& Almaimani, Riyad A.& Althubiti, Mohammad Ahmad& El-Readi, Mahmoud Zaki. 2019. Overexpression of Inducible Nitric Oxide Synthase in Allergic and Nonallergic Nasal Polyp. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1205170
Modern Language Association (MLA)
Sadek, Ahmed Adel…[et al.]. Overexpression of Inducible Nitric Oxide Synthase in Allergic and Nonallergic Nasal Polyp. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1205170
American Medical Association (AMA)
Sadek, Ahmed Adel& Abdelwahab, Soha& Eid, Safaa Yehia& Almaimani, Riyad A.& Althubiti, Mohammad Ahmad& El-Readi, Mahmoud Zaki. Overexpression of Inducible Nitric Oxide Synthase in Allergic and Nonallergic Nasal Polyp. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1205170
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205170