Oxidative Storm Induced by Tryptophan Metabolites: Missing Link between Atherosclerosis and Chronic Kidney Disease
Joint Authors
Kwiatkowska, Iwona
Hermanowicz, Justyna M.
Mysliwiec, Michal
Pawlak, Dariusz
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-30
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Chronic kidney disease (CKD) occurrence is rising all over the world.
Its presence is associated with an increased risk of premature death from cardiovascular disease (CVD).
Several explanations of this link have been put forward.
It is known that in renal failure, an array of metabolites cannot be excreted, and they accumulate in the organism.
Among them, some are metabolites of tryptophan (TRP), such as indoxyl sulfate and kynurenine.
Scientists have become interested in them in the context of inducing vascular damage in the course of chronic kidney impairment.
Experimental evidence suggests the involvement of TRP metabolites in the progression of chronic kidney disease and atherosclerosis separately and point to oxidative stress generation as one of the main mechanisms that is responsible for worsening those states.
Since it is known that blood levels of those metabolites increase significantly in renal failure and that they generate reactive oxygen species (ROS), which lead to endothelial injury, it is reasonable to suspect that products of TRP metabolism are the missing link in frequently occurring atherosclerosis in CKD patients.
This review focuses on reports that shed a light on TRP metabolites as contributing factors to vascular damage in the progression of impaired kidney function.
American Psychological Association (APA)
Kwiatkowska, Iwona& Hermanowicz, Justyna M.& Mysliwiec, Michal& Pawlak, Dariusz. 2020. Oxidative Storm Induced by Tryptophan Metabolites: Missing Link between Atherosclerosis and Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1205183
Modern Language Association (MLA)
Kwiatkowska, Iwona…[et al.]. Oxidative Storm Induced by Tryptophan Metabolites: Missing Link between Atherosclerosis and Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1205183
American Medical Association (AMA)
Kwiatkowska, Iwona& Hermanowicz, Justyna M.& Mysliwiec, Michal& Pawlak, Dariusz. Oxidative Storm Induced by Tryptophan Metabolites: Missing Link between Atherosclerosis and Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1205183
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205183