Effects of Exercise on Inflammatory Cytokines in Patients with Type 2 Diabetes: A Meta-analysis of Randomized Controlled Trials
Joint Authors
Chen, Xiaoke
Sun, Xinzheng
Wang, Chenghao
He, Hui
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objective.
Inflammation is involved in the pathogenesis of type 2 diabetes (T2DM) and the occurrence of insulin resistance.
The purpose of this study was to investigate the effects of exercise on inflammatory factors in patients with T2DM.
Methods.
A systematic review was conducted on five databases, Cochrane, Embase, Pubmed, Web of Science, and EBSCO.
All randomized controlled trials (RCTs) published between establishment of the database and November 2020 without restrictions on language were included.
Studies evaluated the effects of exercise intervention on inflammatory cytokines in patients with T2DM were selected.
Results.
Twenty-three randomized controlled trials (1350 patients) were included in our meta-analysis.
Exercise can significantly reduce the level of C-reactive protein (CRP) (MD: −0.79, 95% CI: −1.26 to −0.33, p=0.0008), tumor necrosis factor-α (TNF-α) (MD: −2.33, 95% CI: −3.39 to −1.27, p<0.0001), and interleukin-6 (IL-6) (MD: −0.42, 95% CI: −0.60 to −0.24, p<0.0001) in T2DM patients.
Conclusion.
The findings of this review suggest that exercise reduces inflammatory cytokines (CRP, TNF-α, and IL-6) in T2DM patients.
More studies with high methodological qualities and large sample sizes need to be done to confirm which forms of exercise are most effective.
American Psychological Association (APA)
Chen, Xiaoke& Sun, Xinzheng& Wang, Chenghao& He, Hui. 2020. Effects of Exercise on Inflammatory Cytokines in Patients with Type 2 Diabetes: A Meta-analysis of Randomized Controlled Trials. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205187
Modern Language Association (MLA)
Chen, Xiaoke…[et al.]. Effects of Exercise on Inflammatory Cytokines in Patients with Type 2 Diabetes: A Meta-analysis of Randomized Controlled Trials. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1205187
American Medical Association (AMA)
Chen, Xiaoke& Sun, Xinzheng& Wang, Chenghao& He, Hui. Effects of Exercise on Inflammatory Cytokines in Patients with Type 2 Diabetes: A Meta-analysis of Randomized Controlled Trials. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205187
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205187