Antioxidants Targeting Mitochondrial Oxidative Stress: Promising Neuroprotectants for Epilepsy
Joint Authors
Zhou, Hong-Hao
Yang, Nan
Guan, Qi-Wen
Chen, Fang-Hui
Xia, Qin-Xuan
Yin, Xi-Xi
Mao, Xiao-Yuan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-25
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Mitochondria are major sources of reactive oxygen species (ROS) within the cell and are especially vulnerable to oxidative stress.
Oxidative damage to mitochondria results in disrupted mitochondrial function and cell death signaling, finally triggering diverse pathologies such as epilepsy, a common neurological disease characterized with aberrant electrical brain activity.
Antioxidants are considered as promising neuroprotective strategies for epileptic condition via combating the deleterious effects of excessive ROS production in mitochondria.
In this review, we provide a brief discussion of the role of mitochondrial oxidative stress in the pathophysiology of epilepsy and evidences that support neuroprotective roles of antioxidants targeting mitochondrial oxidative stress including mitochondria-targeted antioxidants, polyphenols, vitamins, thiols, and nuclear factor E2-related factor 2 (Nrf2) activators in epilepsy.
We point out these antioxidative compounds as effectively protective approaches for improving prognosis.
In addition, we specially propose that these antioxidants exert neuroprotection against epileptic impairment possibly by modulating cell death interactions, notably autophagy-apoptosis, and autophagy-ferroptosis crosstalk.
American Psychological Association (APA)
Yang, Nan& Guan, Qi-Wen& Chen, Fang-Hui& Xia, Qin-Xuan& Yin, Xi-Xi& Zhou, Hong-Hao…[et al.]. 2020. Antioxidants Targeting Mitochondrial Oxidative Stress: Promising Neuroprotectants for Epilepsy. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1205194
Modern Language Association (MLA)
Yang, Nan…[et al.]. Antioxidants Targeting Mitochondrial Oxidative Stress: Promising Neuroprotectants for Epilepsy. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1205194
American Medical Association (AMA)
Yang, Nan& Guan, Qi-Wen& Chen, Fang-Hui& Xia, Qin-Xuan& Yin, Xi-Xi& Zhou, Hong-Hao…[et al.]. Antioxidants Targeting Mitochondrial Oxidative Stress: Promising Neuroprotectants for Epilepsy. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1205194
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205194