Modified Huang-Lian-Jie-Du Decoction Ameliorates Aβ Synaptotoxicity in a Murine Model of Alzheimer’s Disease
Joint Authors
Zhang, Yunlong
Qian, Lin-chao
Huang, Shuqiong
Chen, Chaojun
Xu, Pingyi
Liu, Yan
Du, Ting
Zhang, Wenlong
Lu, Weiye
Peng, Zhichao
Sun, Xiangdong
Zhu, Xiaoqin
Wen, Lei
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-27, 27 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-03
Country of Publication
Egypt
No. of Pages
27
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is a common neurodegenerative disease, characterized by cognitive dysfunction; however, the therapeutic strategies are not fully understood.
Huang-Lian-Jie-Du-Decoction (HLJDD) is a famous traditional Chinese herbal formula that has been widely used clinically to treat dementia.
Recently, according to previous study and our clinical practice, we generate a new modification of HLJDD (named modified-HLJDD).
In this study, we indicated that modified-HLJDD attenuated learning and memory deficiencies in Aβ1-42 oligomer-induced AD model, and we confirmed the exact metabolites in modified-HLJDD solution, as compared with HLJDD by UHPLC-Q-TOF-MS.
Using GC-Q-TOF/MS-based metabolomics, we identified adenosine as the potential significant metabolite, responsible for modified-HLJDD regulating energy metabolism and synaptic plasticity in AD model.
We also revealed that the potential underlying mechanism of modified-HLJDD in AD model may involve NMDA receptor-mediated glutamatergic transmission and adenosine/ATPase/AMPK cascade.
Moreover, we also indicated the differential gut microbiota which mainly involved Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria at the phylum level upon modified-HLJDD treatment in AD model.
Based on the correlation of metabolomic analysis with microbiome analysis, we clarified that Dorea is the most affected microbiota with adenosine upon modified-HLJDD treatment in AD model.
Thus, our study suggests that modified-HLJDD may serve as a potential therapeutic drug in treating AD.
American Psychological Association (APA)
Liu, Yan& Du, Ting& Zhang, Wenlong& Lu, Weiye& Peng, Zhichao& Huang, Shuqiong…[et al.]. 2019. Modified Huang-Lian-Jie-Du Decoction Ameliorates Aβ Synaptotoxicity in a Murine Model of Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-27.
https://search.emarefa.net/detail/BIM-1205635
Modern Language Association (MLA)
Liu, Yan…[et al.]. Modified Huang-Lian-Jie-Du Decoction Ameliorates Aβ Synaptotoxicity in a Murine Model of Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-27.
https://search.emarefa.net/detail/BIM-1205635
American Medical Association (AMA)
Liu, Yan& Du, Ting& Zhang, Wenlong& Lu, Weiye& Peng, Zhichao& Huang, Shuqiong…[et al.]. Modified Huang-Lian-Jie-Du Decoction Ameliorates Aβ Synaptotoxicity in a Murine Model of Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-27.
https://search.emarefa.net/detail/BIM-1205635
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205635