Oxidative Stress Mediates Anxiety-Like Behavior Induced by High Caffeine Intake in Zebrafish: Protective Effect of Alpha-Tocopherol
Joint Authors
de Carvalho, Tayana Silva
Cardoso, Patrick Bruno
Santos-Silva, Mateus
Lima-Bastos, Sávio
Luz, Waldo Lucas
Assad, Nadyme
Kauffmann, Nayara
Passos, Adelaide
Brasil, Alódia
Bahia, Carlomagno Pacheco
Moraes, Suellen
Gouveia, Amauri
de Jesus Oliveira Batista, Evander
Oliveira, Karen Renata Matos Herculano
Herculano, Anderson Manoel
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Anxiety is a common symptom associated with high caffeine intake.
Although the neurochemical mechanisms of caffeine-induced anxiety remain unclear, there are some evidences suggesting participation of oxidative stress.
Based on these evidences, the current study is aimed at evaluating the possible protective effect of alpha-tocopherol (TPH) against anxiety-like behavior induced by caffeine (CAF) in zebrafish.
Adult animals were treated with CAF (100 mg/kg) or TPH (1 mg/kg)+CAF before behavioral and biochemical evaluations.
Oxidative stress in the zebrafish brain was evaluated by a lipid peroxidation assay, and anxiety-like behavior was monitored using light/dark preference and novel tank diving test.
Caffeine treatment evoked significant elevation of brain MDA levels in the zebrafish brain, and TPH treatment prevented this increase.
Caffeine treatment also induced anxiety-like behavior, while this effect was not observed in the TPH+CAF group.
Taken together, the current study suggests that TPH treatment is able to inhibit oxidative stress and anxiety-like behavior evoked by caffeine.
American Psychological Association (APA)
Brasil, Alódia& Bahia, Carlomagno Pacheco& Moraes, Suellen& Gouveia, Amauri& de Jesus Oliveira Batista, Evander& Oliveira, Karen Renata Matos Herculano…[et al.]. 2019. Oxidative Stress Mediates Anxiety-Like Behavior Induced by High Caffeine Intake in Zebrafish: Protective Effect of Alpha-Tocopherol. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1205667
Modern Language Association (MLA)
Brasil, Alódia…[et al.]. Oxidative Stress Mediates Anxiety-Like Behavior Induced by High Caffeine Intake in Zebrafish: Protective Effect of Alpha-Tocopherol. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1205667
American Medical Association (AMA)
Brasil, Alódia& Bahia, Carlomagno Pacheco& Moraes, Suellen& Gouveia, Amauri& de Jesus Oliveira Batista, Evander& Oliveira, Karen Renata Matos Herculano…[et al.]. Oxidative Stress Mediates Anxiety-Like Behavior Induced by High Caffeine Intake in Zebrafish: Protective Effect of Alpha-Tocopherol. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1205667
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205667