Pharmacological Modulation of Cardiac Remodeling after Myocardial Infarction
Joint Authors
Rong, Jianhui
Zhao, Jia
Zhao, Wei
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Cardiac remodeling describes a series of structural and functional changes in the heart after myocardial infarction (MI).
Adverse post-MI cardiac remodeling directly jeopardizes the recovery of cardiac functions and the survival rate in MI patients.
Several classes of drugs are proven to be useful to reduce the mortality of MI patients.
However, it is an ongoing challenge to prevent the adverse effects of cardiac remodeling.
The present review aims to identify the pharmacological therapies from the existing clinical drugs for the treatment of adverse post-MI cardiac remodeling.
Post-MI cardiac remodeling is a complex process involving ischemia/reperfusion, inflammation, cell death, and deposition of extracellular matrix (ECM).
Thus, the present review included two parts: (1) to examine the basic pathophysiology in the cardiovascular system and the molecular basis of cardiac remodeling and (2) to identify the pathological aspects of cardiac remodeling and the potential of the existing pharmacotherapies.
Ultimately, the present review highlights drug repositioning as a strategy to discover effective therapies from the existing drugs against post-MI cardiac remodeling.
American Psychological Association (APA)
Zhao, Wei& Zhao, Jia& Rong, Jianhui. 2020. Pharmacological Modulation of Cardiac Remodeling after Myocardial Infarction. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1205702
Modern Language Association (MLA)
Zhao, Wei…[et al.]. Pharmacological Modulation of Cardiac Remodeling after Myocardial Infarction. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1205702
American Medical Association (AMA)
Zhao, Wei& Zhao, Jia& Rong, Jianhui. Pharmacological Modulation of Cardiac Remodeling after Myocardial Infarction. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1205702
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205702