β-Lapachone Increases Survival of Septic Mice by Regulating Inflammatory and Oxidative Response
Joint Authors
de B. Oliveira, Ana L.
Navegantes-Lima, Kely C.
Monteiro, Valter V. S.
Quadros, Lucas B. G.
de Oliveira, Juliana P.
dos Santos, Sávio M.
de A. Pontes, Anna C. A.
Dorneles, Gilson P.
Júnior, Luiz C. R.
de Oliveira, Alaíde B.
Monteiro, Marta C.
Romão, Pedro R. T.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Sepsis is characterized by a dysregulated immune response to infection characterized by an early hyperinflammatory and oxidative response followed by a subsequent immunosuppression phase.
Although there have been some advances in the treatment of sepsis, mortality rates remain high, urging for the search of new therapies.
β-Lapachone (β-Lap) is a natural compound obtained from Tabebuia avellanedae Lorentz ex Griseb.
with several pharmacological properties including bactericidal, anti-inflammatory, and antioxidant activity.
Thus, the aim of this study was to evaluate the effects of β-Lap in a mouse sepsis model.
To this, we tested two therapeutic protocols in mice submitted to cecal ligation and puncture- (CLP-) induced sepsis.
First, we found that in pretreated animals, β-Lap reduced the systemic inflammatory response and improved bacterial clearance and mouse survival.
Moreover, β-Lap also decreased lipid peroxidation and increased the total antioxidant capacity in the serum and peritoneal cavity of septic animals.
In the model of severe sepsis, the posttreatment with β-Lap was able to increase the survival of animals and maintain the antioxidant defense function.
In conclusion, the β-Lap was able to increase the survival of septic animals by a mechanism involving immunomodulatory and antioxidant protective effects.
American Psychological Association (APA)
de B. Oliveira, Ana L.& Navegantes-Lima, Kely C.& Monteiro, Valter V. S.& Quadros, Lucas B. G.& de Oliveira, Juliana P.& dos Santos, Sávio M.…[et al.]. 2020. β-Lapachone Increases Survival of Septic Mice by Regulating Inflammatory and Oxidative Response. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205722
Modern Language Association (MLA)
de B. Oliveira, Ana L.…[et al.]. β-Lapachone Increases Survival of Septic Mice by Regulating Inflammatory and Oxidative Response. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1205722
American Medical Association (AMA)
de B. Oliveira, Ana L.& Navegantes-Lima, Kely C.& Monteiro, Valter V. S.& Quadros, Lucas B. G.& de Oliveira, Juliana P.& dos Santos, Sávio M.…[et al.]. β-Lapachone Increases Survival of Septic Mice by Regulating Inflammatory and Oxidative Response. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205722
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205722