Antioxidant and α-Glucosidase Inhibitory Activities Guided Isolation and Identification of Components from Mango Seed Kernel
Joint Authors
Zhai, Jianxiu
Han, Na
Chen, Xuee
Liu, Xida
Liu, Zhihui
Li, Sikai
Yin, Jun
Yang, Dan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-29
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
In the present study, petroleum ether, dichloromethane, ethyl acetate, and n-butanol fractions of mango seed kernel exhibited different degrees of antioxidant and α-glucosidase inhibitory activity.
Thus, quantitative and qualitative analysis of the petroleum ether fraction was conducted by GC-MS.
Among identified components, four unsaturated fatty acids had never been reported in natural products before, together with 19 known components.
In addition, 17 compounds were isolated and elucidated from other active fractions.
Compounds 2, 9, 15, and 17 were isolated for the first time from Mangifera genus.
Compounds 1 and 2 exhibited prominent DPPH radical scavenging and α-glucosidase inhibitory effects.
In order to further explore their mechanism of α-glucosidase inhibition, their enzyme kinetics and in silico modeling experiments were performed.
The results indicated that 1 inhibited α-glucosidase in a noncompetitive manner, whereas 2 acted in a competitive manner.
In molecular docking, the stability of binding was enhanced by π-π T-shaped, π-alkyl, π-π stacked, hydrogen bond, and electrostatic interactions.
Thus, compounds 1 and 2 were determined to be new potent antioxidant and α-glucosidase inhibitors for preventing food oxidation and enhancing hypoglycemic activity.
American Psychological Association (APA)
Yang, Dan& Chen, Xuee& Liu, Xida& Han, Na& Liu, Zhihui& Li, Sikai…[et al.]. 2020. Antioxidant and α-Glucosidase Inhibitory Activities Guided Isolation and Identification of Components from Mango Seed Kernel. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1205791
Modern Language Association (MLA)
Yang, Dan…[et al.]. Antioxidant and α-Glucosidase Inhibitory Activities Guided Isolation and Identification of Components from Mango Seed Kernel. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1205791
American Medical Association (AMA)
Yang, Dan& Chen, Xuee& Liu, Xida& Han, Na& Liu, Zhihui& Li, Sikai…[et al.]. Antioxidant and α-Glucosidase Inhibitory Activities Guided Isolation and Identification of Components from Mango Seed Kernel. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1205791
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205791