Autophagy and Redox Homeostasis in Parkinson’s: A Crucial Balancing Act
Joint Authors
Jimenez-Moreno, Natalia
Lane, Jon D.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-38, 38 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-10
Country of Publication
Egypt
No. of Pages
38
Main Subjects
Abstract EN
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated primarily from endogenous biochemical reactions in mitochondria, endoplasmic reticulum (ER), and peroxisomes.
Typically, ROS/RNS correlate with oxidative damage and cell death; however, free radicals are also crucial for normal cellular functions, including supporting neuronal homeostasis.
ROS/RNS levels influence and are influenced by antioxidant systems, including the catabolic autophagy pathways.
Autophagy is an intracellular lysosomal degradation process by which invasive, damaged, or redundant cytoplasmic components, including microorganisms and defunct organelles, are removed to maintain cellular homeostasis.
This process is particularly important in neurons that are required to cope with prolonged and sustained operational stress.
Consequently, autophagy is a primary line of protection against neurodegenerative diseases.
Parkinson’s is caused by the loss of midbrain dopaminergic neurons (mDANs), resulting in progressive disruption of the nigrostriatal pathway, leading to motor, behavioural, and cognitive impairments.
Mitochondrial dysfunction, with associated increases in oxidative stress, and declining proteostasis control, are key contributors during mDAN demise in Parkinson’s.
In this review, we analyse the crosstalk between autophagy and redoxtasis, including the molecular mechanisms involved and the detrimental effect of an imbalance in the pathogenesis of Parkinson’s.
American Psychological Association (APA)
Jimenez-Moreno, Natalia& Lane, Jon D.. 2020. Autophagy and Redox Homeostasis in Parkinson’s: A Crucial Balancing Act. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-38.
https://search.emarefa.net/detail/BIM-1205813
Modern Language Association (MLA)
Jimenez-Moreno, Natalia& Lane, Jon D.. Autophagy and Redox Homeostasis in Parkinson’s: A Crucial Balancing Act. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-38.
https://search.emarefa.net/detail/BIM-1205813
American Medical Association (AMA)
Jimenez-Moreno, Natalia& Lane, Jon D.. Autophagy and Redox Homeostasis in Parkinson’s: A Crucial Balancing Act. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-38.
https://search.emarefa.net/detail/BIM-1205813
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205813