Mitochondrial F-ATP Synthase and Its Transition into an Energy-Dissipating Molecular Machine
Joint Authors
Lippe, Giovanna
Coluccino, Gabriele
Zancani, Marco
Baratta, Walter
Crusiz, Paola
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The mitochondrial F-ATP synthase is the principal energy-conserving nanomotor of cells that harnesses the proton motive force generated by the respiratory chain to make ATP from ADP and phosphate in a process known as oxidative phosphorylation.
In the energy-converting membranes, F-ATP synthase is a multisubunit complex organized into a membrane-extrinsic F1 sector and a membrane-intrinsic FO domain, linked by central and peripheral stalks.
Due to its essential role in the cellular metabolism, malfunction of F-ATP synthase has been associated with a variety of pathological conditions, and the enzyme is now considered as a promising drug target for multiple disease conditions and for the regulation of energy metabolism.
We discuss structural and functional features of mitochondrial F-ATP synthase as well as several conditions that partially or fully inhibit the coupling between the F1 catalytic activities and the FO proton translocation, thus decreasing the cellular metabolic efficiency and transforming the enzyme into an energy-dissipating structure through molecular mechanisms that still remain to be defined.
American Psychological Association (APA)
Lippe, Giovanna& Coluccino, Gabriele& Zancani, Marco& Baratta, Walter& Crusiz, Paola. 2019. Mitochondrial F-ATP Synthase and Its Transition into an Energy-Dissipating Molecular Machine. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1205889
Modern Language Association (MLA)
Lippe, Giovanna…[et al.]. Mitochondrial F-ATP Synthase and Its Transition into an Energy-Dissipating Molecular Machine. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1205889
American Medical Association (AMA)
Lippe, Giovanna& Coluccino, Gabriele& Zancani, Marco& Baratta, Walter& Crusiz, Paola. Mitochondrial F-ATP Synthase and Its Transition into an Energy-Dissipating Molecular Machine. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1205889
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205889